To clarify the contribution of humoral factors to blood pressure changes produced by stimulation of the central nervous system, successive determination of arterial catecholamine (CA) concentration by fluorimetric method was performed. In the case of prolonged maintenance of blood pressure elevation after the stimulation, CA increased remarkably. By the experiments of ligation of the adrenal veins, section of the greater splanchnic nerves, stimulation of the greater splanchnic nerve, and intravenous injection of epinephrine, it was concluded that during stimulation of the central nervous system the neural mechanism affected the vascular system to elevate blood pressure and also affected the adrenals through the greater splanchnic nerves to secrete humoral factors, CA especially epinephrine, which maintained the rise in blood pressure after the stimulation. Despite the prolonged elevation after stimulation, the increase in CA was transient. The secretion of CA was remarkable in the cases of stimulation of the central gray stratum of the midbrain.
Clinical and pathological studies on 56 cases of cerebral embolism were made among 1,029 admitted cardiac patients. The incidence of cerebral embolism was greatest in mitral valvular disease. The age of patients and the intervals between the episodes were studied. The relationship of the occurrence of cerebral embolism to the atrial fibrillation, the heart size, administration of digitalis and congestive failure was also examined. The laterality of hemiplegia was not obvious. Recoveries from the mental disturbance was complete in 79% of 42 cases. In autopsied cases, a correlation between cerebral embolism and mural thrombosis was found, and the locations of lesions in the brain and involved arteries were also studied.
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