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Aim Infertility is a concern for young colorectal cancer (CRC) survivors, but this risk is not well quantified. Mismatch repair (MMR) mutation carriers are a useful cohort for studying fertility after CRC as they commonly develop CRC when young, and unaffected family members provide demographically similar controls. The aim of this study was to determine the effect of CRC on fertility in a large cohort of MMR mutation carriers. Method MMR mutation carriers identified from the Australasian Colorectal Cancer Family Registry were included. For each year of life within the fertile age range (15 to 49), the number of living individuals and the number of children born to them were determined. Individuals were grouped by whether or not they had had a diagnosis of CRC by that age. Age-specific and total fertility rates were calculated. Results 1068 subjects (611 women and 457 men) were identified, of whom 467 were diagnosed with CRC. There were 1,192 births during 18674 person- years of follow up of the women and 814 births during 14013 person- years of follow up to the men. The total fertility rate was decreased in women after a diagnosis of CRC compared who did not have CRC (1.3 vs. 2.2 P=0.0011), but age- specific fertility was only reduced in the 20–24 year age group. In men TFR was similar for both groups (2.0 vs. 1.8) P = 0.27). Conclusion Age- specific fertility was decreased in female CRC survivors with Lynch syndrome aged 20–24, but not in older women or in men.

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Win et al.: A study of cancer risks in relatives of patients with serrated polyposis. Hereditary Cancer in Clinical Practice 2012 10(Suppl 2):A21.