Association of Lynch syndrome and risk of invasive cervical cancer.

Review of findings in prophylactic gynaecological specimens in Lynch syndrome with literature review and recommendations for grossing

“…described a case of cervical adenocarcinoma with focal papillary serous features arising in a patient with Muir–Torre syndrome, but there was no mention of testing the tumour for MSI and MMR‐IHC. Antill et al . identified 66 cases of cervical cancer among 369 families with MMR gene mutations.…”

“…In the series by Mills et al ., the cervical adenocarcinoma in a known LS patient was shown to be MMR‐IHC intact and hence most probably a sporadic tumour. The work by Antill et al . is interesting, but is limited by lack of access to diagnostic material for contemporary work‐up and classification of these lesions.…”

“…In the series by Mills et al, 26 the cervical adenocarcinoma in a known LS patient was shown to be MMR-IHC intact and hence most probably a sporadic tumour. The work by Antill et al 44 is interesting, but is limited by lack of access to diagnostic material for contemporary work-up and classification of these lesions. In terms of grossing recommendations in a research setting the cervix could be examined in toto, but practically, in the absence of a visible lesion, we suggest taking four sections, one anterior, one posterior, one right and one left lateral.…”

“…Nair et al 43 described a case of cervical adenocarcinoma with focal papillary serous features arising in a patient with Muir-Torre syndrome, but there was no mention of testing the tumour for MSI and MMR-IHC. Antill et al 44 identified 66 cases of cervical cancer among 369 families with MMR gene mutations. The pathology reports were only available in 12 of these cases, eight of which (67%) had been reported as adenocarcinoma or a mixed histology with a predominance of adenocarcinoma.…”