Abstract. Covid-19 is an infectious disease caused by the Coronavirus 2 of the Severe Acute Respiratory Syndrome. It was predicted to appear in 2020. As a result of the pandemic, Work From Home has been established for the entire population, including youths and students who are afflicted. Restrictions on outside activities resulted in a variety of lifestyle modifications, including changes in physical activity and food. A high-calorie diet combined with insufficient physical activity might cause health concerns in teens. The goal of this study is to look at the description of physical activity and eating patterns in adolescents at SMA Negeri 4 Metro during the pandemic. This study is descriptive in nature. Proportional stratified random sampling was used to determine the sample size in this investigation. The Global Physical Activity Questionnaire and the Food Frequency Questionnaire were used to collect data. This study found that during the Covid-19 epidemic, 56.4 percent of teenagers engaged in moderate physical activity, 22.7 percent engaged in high physical activity, and 10.9 percent engaged in poor physical activity. Adolescents who engage in moderate to high physical activity eat foods with a typical number of calories, whereas adolescents who engage in low physical activity eat foods with a high number of calories. During the Covid-19 epidemic, teenagers ate breakfast six times per week, snacks three times per week, fast food three times per week, and supplements and veggies three times per week. Abstrak. Covid-19 merupakan penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 dan ditetapkan menjadi pandemi pada tahun 2020. Pandemi ini menyebabkan ditetapkannya Work From Home untuk seluruh masyarakat, termasuk remaja atau siswa yang bersekolah. Pembatasan aktivitas di luar rumah mengakibatkan terjadinya beberapa perubahan pola hidup termasuk perubahan aktivitas fisik dan pola makan. Pada remaja yang aktivitas fisiknya sedikit dengan pola makan yang memliki kalori tinggi dapat menyebabkan permasalahan kesehatan. Penelitian ini bertujuan untuk menganalisis bagaimana gambaran aktivitas fisik dan pola makan selama pandemi pada remaja di SMA Negeri 4 Metro. Penelitian ini merupakan penelitian deskriptif. Besar sampel dalam penelitian ini diambil dengan cara Proportionate Stratified Random Sampling. Data dikumpulkan dengan menggunakan Global Physical Activity Questionnaire dan Formulir Food Frequency Questionnaire. Hasil yang didapatkan dalam penelitian ini yaitu jumlah presentase remaja selama pandemi Covid-19 melakukan aktivitas fisik sedang sebayak 56.4%, aktivitas fisik tinggi 22.7% dan aktivitas fisik rendah 10.9%. Remaja dengan aktivitas fisik sedang dan aktivitas tinggi mengkonsumsi makanan dengan jumlah kalori yang normal, sedangkan remaja beraktivitas fisik rendah mengkonsumsi makanan dengan jumlah kalori tinggi. Kebiasaan pola makan remaja selama pandemi Covid-19 adalah mengkonsumsi sarapan sebanyak 6 kali/minggu, mengkonsumsi jajan sebanyak 3-5 kali/minggu, mengkonsumsi Fastfood sebanyak 3-5 kali/minggu dan mengkonsumsi suplemen dan sayur sebanyak 3-5 kali/minggu.
Objective: To evaluate the potency of the fraction of marine sponge Stylissa carteri in inducing cell death, inhibiting spheroid growth, and its impact on pro-apoptotic protein Mcl-1S in breast cancer cells. Methods: Stylissa carteri were collected from Pramuka Island followed by ethanol extraction and ethyl acetate fractionation. To evaluate the cytotoxic effect of fraction, the HCC-1954, MDA MB 231, and MCF-7 cells were treated with the fraction of Stylissa carteri and MTT assay was then performed. The effect on spheroid growth was evaluated in HCC-1954 cells. The combined effect of the ethyl acetate fraction and paclitaxel were analyzed using combination index (CI) and immunoblotting on the pro-apoptotic protein Mcl-1S. Furthermore, compounds in this fraction were identified using GC-MS. Results: Data showed that both the MDA MB 231 and HCC-1954 cells were interestingly more sensitive to the fraction as compared with MCF-7 cells. The IC 50 of the ethyl acetate fraction on HCC-1954, MDA MB 231 and MCF-7 were 4.1 µg/ml, 3.9 µg/ml, and 123.8 µg/ml, respectively. In addition, the fraction triggered spheroid destruction within 10 days. The CI of paclitaxel and ethyl acetate fraction of Stylissa carteri were less than 0.52. Moreover, this combination induced upregulation of the Mcl-1S protein. Furthermore, some fatty acid-based structures were predicted as the major compounds in this fraction. Conclusion: The ethyl acetate fraction of Stylissa carteri induces cell death and spheroid destruction in aggressive breast cancer cells. It has a synergistic cytotoxic effect with paclitaxel on MDA MB 231 cell death and upregulates Mcl-1S protein.
Abstract. Game online are games that are played at the same time even though they are not played in the same place. Faculty of Medicine students are students who are currently studying medical studies. Faculty of Medicine students are known for their busy schedules and many assignments, so they play game online to overcome boredom. Game online addiction can be understood as an excessive attitude towards the use of digital tools to play game online, makes players unable to control attitudes and emotions caused by excessive attitudes, and can have an impact on social behavior problems, especially at the emotional level. The purpose of this study was to analyze the relationship between game online addiction and emotional levels in medical students at the Islamic University of Bandung. In the results of this study it was revealed that of the 114 students of the Faculty of Medicine at the Islamic University of Bandung, the dominant ones were not addicted to game online (81.6%) and had good emotions in playing game online (66.7%). From the results of this study it was found that the value of P = 0.490 which stated that there was no relationship between game online addiction and emotional levels in students of the Faculty of Medicine, Islamic University of Bandung. This is based on the existence of several things that can affect emotional levels such as student achievement and also good emotional intelligence. Abstrak. Game online adalah game yang dimainkan dalam waktu yang bersamaan walaupun tidak dimainkan di tempat yang sama. Mahasiswa Fakultas Kedokteran merupakan mahasiswa yang sedang belajar dalam studi kedokteran. Mahasiswa Fakultas Kedokteran dikenal dengan jadwal yang padat dan juga tugas yang banyak, sehingga mereka bermain game online untuk mengatasi jenuh. Kecanduan game online dapat dipahami sebagai sikap berlebihan terhadap penggunaan alat digital untuk bermain game online, membuat pemain tidak dapat mengontrol sikap dan emosi yang disebabkan oleh sikap berlebihan, dan dapat berdampak pada masalah perilaku sosial terutama pada tingkat emosional. Tujuan dari penelitian ini adalah untuk menganalisa hubungan kecanduan game online terhadap tingkat emosi pada mahasiswa fakultas kedokteran Universitas Islam Bandung. Pada hasil penelitian ini terungkap bahwa dari 114 orang mahasiswa Fakultas Kedokteran Universitas Islam Bandung dominan tidak mengalami kecanduan game online (81,6 %) dan memiliki emosi baik dalam bermain game online (66,7%). Dari hasil penelitian tersebut didapatkan bahwa nilai P = 0,490 yang menyatakan bahwa tidak terdapat adanya hubungan antara kecanduan game online terhadap tingkat emosi pada mahasiswa Fakultas Kedokteran Universitas Islam Bandung. Hal tersebut didasarkan pada adanya beberapa hal yang dapat mempengaruhi tingkat emosi seperti prestasi belajar mahasiswa dan juga kecerdasan emosional yang bagus.
Abstract. Covid-19 is an infectious disease caused by the Coronavirus 2 of the Severe Acute Respiratory Syndrome. It was predicted to appear in 2020. As a result of the pandemic, Work From Home has been established for the entire population, including youths and students who are afflicted. Restrictions on outside activities resulted in a variety of lifestyle modifications, including changes in physical activity and food. A high-calorie diet combined with insufficient physical activity might cause health concerns in teens. The goal of this study is to look at the description of physical activity and eating patterns in adolescents at SMA Negeri 4 Metro during the pandemic. This study is descriptive in nature. Proportional stratified random sampling was used to determine the sample size in this investigation. The Global Physical Activity Questionnaire and the Food Frequency Questionnaire were used to collect data. This study found that during the Covid-19 epidemic, 56.4 percent of teenagers engaged in moderate physical activity, 22.7 percent engaged in high physical activity, and 10.9 percent engaged in poor physical activity. Adolescents who engage in moderate to high physical activity eat foods with a typical number of calories, whereas adolescents who engage in low physical activity eat foods with a high number of calories. During the Covid-19 epidemic, teenagers ate breakfast six times per week, snacks three times per week, fast food three times per week, and supplements and veggies three times per week. Abstrak. Covid-19 merupakan penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 dan di tetapkan menjadi pandemi pada tahun 2020. Pandemi ini menyebabkan ditetapkannya Work From Home untuk seluruh masyarakat, termasuk remaja atau siswa yang bersekolah. Pembatasan aktivitas di luar rumah mengakibatkan terjadinya beberapa perubahan pola hidup termasuk perubahan aktivitas fisik dan pola makan. Pada remaja yang aktivitas fisiknya sedikit dengan pola makan yang memliki kalori tinggi dapat menyebabkan permasalahan kesehatan. Penelitian ini bertujuan untuk menganalisis bagaimana gambaran aktivitas fisik dan pola makan selama pandemi pada remaja di SMA Negeri 4 Metro. Penelitian ini merupakan penelitian deskriptif. Besar sampel dalam penelitian ini diambil dengan cara Proportionate Stratified Random Sampling. Data dikumpulkan dengan menggunakan Global Physical Activity Questionnaire dan Formulir Food Frequency Questionnaire. Hasil yang didapatkan dalam penelitian ini yaitu jumlah presentase remaja selama pandemi Covid-19 melakukan aktivitas fisik sedang sebayak 56.4%, aktivitas fisik tinggi 22.7% dan aktivitas fisik rendah 10.9%. Remaja dengan aktivitas fisik sedang dan aktivitas tinggi mengkonsumsi makanan dengan jumlah kalori yang normal, sedangkan remaja beraktivitas fisik rendah mengkonsumsi makanan dengan jumlah kalori tinggi. Kebiasaan pola makan remaja selama pandemi Covid-19 adalah mengkonsumsi sarapan sebanyak 6 kali/minggu, mengkonsumsi jajan sebanyak 3-5 kali/minggu, mengkonsumsi Fastfood sebanyak 3-5 kali/minggu dan mengkonsumsi suplemen dan sayur sebanyak 3-5 kali/minggu.
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