Introduction: Thalassaemia Major patients require frequent blood transfusion leading to iron overload. Excessive iron gets deposited in vital organs and leads to dysfunction of the heart, liver, anterior pituitary, pancreas, and joints. Our body has limited mechanism to excrete iron, so patients with iron overload and its complications need safe and effective iron chelation therapy. Aim:To assess the efficacy of Deferasirox (DFX) as an iron chelator, with specific reference to reduction in serum ferritin level. Materials and Methods:This is a prospective; observational study done in 45 multitransfused Thalassaemia Major Children receiving DFX therapy at registered Thalassaemia society Raipur Chhattisgarh. DFX was given in an initial dose of 20 mg/kg/day and according to response increased to a maximum of 40 mg/kg/ day. Serum ferritin level was estimated at time of registration and at every three monthly intervals (four times during study period). The primary end point of the study was change in serum ferritin level after 12 months of DFX therapy. Results:The mean serum ferritin before DFX therapy of all cases was 3727.02 ng/mL. After 12 months of mean dose of 38 mg/kg/ day of DFX, the mean decline in serum ferritin was 1207.11 ng/ mL (drop by 32.38%, p-value <0.001).Conclusion: DFX monotherapy has a good safety profile and effectively chelates total body iron in Thalassaemia major patients.Shikha Jaiswal et al., Efficacy of Deferasirox as an Oral Iron Chelator in Paediatric Thalassaemia Patients www.jcdr.net
BACKGROUND:India is a developing country and adverse drug reactions (ADRs) influence most of the diseases in our population, and monitoring is required due to the paucity of ADRs. The present study was done to analyze the ADRs at the ADR monitoring center (AMC) of tertiary care hospital in Raipur during 1 year.MATERIALS AND METHODS:Study of ADR monitoring of outpatient and inpatient was a prospective and observational study carried out between September 2015 and August 2016. The ADRs in the form of Individual Case Safety Report (ICSR) was sent to the Indian database (Vigiflow®).RESULTS:Total ICSRs reported to Vigiflow® were 232 during 1 year. Among them, 63.79% were found to be nonserious and 36.21% were serious. Nearly 45% of ADRs were implicated only due to antimicrobials, which is highest among all other groups of drugs. A maximum number of ADRs were observed in 31–60 years of age group (52.15%). In causality assessment, the probable cases had a higher incidence (67.24%), followed by possible (27.58%) and certain (4.74%). The frequency of ADR reporting at our AMC was low (0.043%) compared to national average. Our AMC shared 0.35% of total ICSRs, which is insignificant (P < 0.001) compared to the JSS, Mysore and PGIMER, Chandigarh, AMCs, which have shared most of the ICSRs in Vigiflow®.CONCLUSIONS:The frequencies of ADRs reporting in our study are less compared to those reported with other similar studies. Underreporting is a very serious concern in Raipur, and Pharmacovigilance Programme of India must intercede to pick up ADRs across the country.
Background: in the recent past dermatophytosis are being highly prevalent, main culprit behind is inappropriate use of antifungal agents and self-medications which is leading to exponential rise in global burden superficial fungal infections, and antifungal drug resistance. Clinician's management pattern data collection on time to time to have a check on the resistance/sensitivity pattern of the commonly prescribed antifungals in clinical grounds is important. Aims and objectives: The present study was to describe the pattern of antifungal drug prescription and self-medication for common superficial fungal infections of skin in dermatology OPD in tertiary care hospital of Chhattisgarh. Materials and Methods: Current study was a cross sectional unicentric study conducted at Dermatology OPD of Pt J.N.M. Medical College Raipur, the data collection for this observational study was undertaken for a period of six months. All patients attending the dermatology OPD with tinea infections were included in the study. This study was designed to record parameters include information related to demographic, disease profile, medications prescribed, number of drugs, dosage & duration were reported. Self medication pattern was also being observed during this study. Results: A total of 17286 patients attended dermatology OPD and 42% patients were suffering from tinea. The most common fungal infection was Tinea cruris 55.07%, the commonest treatment pattern was Combination of oral &Topical therapy 92.15%. Most frequently prescribed combination was fluconazole plus itraconazole along with Clotrimazole cream was seen in 64.45%, commonest anti-fungal agents were the azoles; amongst which clotrimazole (67.04%)were the commonest. Commonly prescribed individual antifungal was oral Fluconazole 73.11%. The self-medication prevalence for dermatophytosis was 62.26%. Self-medication drugs were mainly topical (creams) FDC of antifungal and steroids. Around 76% of the self-medication information was obtained from the chemists.
Objectives: To evaluate the potential association between antipsychotics (Olanzapine, Risperidone and Haloperidol), serum glucose level and serum cholesterol level in schizophrenic patients. Introduction: Schizophrenia is quite prevalent and has high rate of chronicity and morbidity. Newer atypical antipsychotic drugs were developed in response to limitations such as lack of efficacy and side effects associated with older (conventional) agents. However, significant hyperglycemia, dyslipidemia and weight gain have been reported with the use of newer atypical antipsychotics. Materials and Methods: This was an observational prospective study. Total 75 schizophrenic patients were divided in three groups according to treatment allocated (group I-olanzapine, group II-risperidone, group III haloperidol) comprising of 25 patients in each group. Blood sample was collected when patient came to hospital for the first time before starting the treatment and 6 weeks after treatment, then again 6 months after treatment, fasting serum glucose and cholesterol levels were estimated by enzymatic procedure. Simultaneously body weight was also measured. Results: In this study majority of patients were male-73.33% with mean age of 30.76 years. There were significant increase in serum glucose levels and serum cholesterol level, after 6 weeks and 6 months of treatment (t=3.11 p<0.01, t = 4.32 p <0.001 respectively) and (t = 1.98 p<0.05. t=3.65 p < 0.001 respectively), In Group I (Olanzapine treated patients). Body weight was also significantly increased (t=3.11, p<0.001).There were no significant increase in serum glucose levels, serum cholesterol levels and body weights in Group II (Risperidone treated group) and Group III (Haloperidol treated group). Conclusion:Olanzapine was associated with increased risk of glucose intolerance, dyslipidemia and weight gain.
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