Background: Little is known about the efficacy of commonly used acid suppressants on intragastric pH in dogs. Objective: To compare the effect of oral famotidine, 2 formulations of omeprazole, and placebo on intragastric pH in dogs with a catheter-free, continuous pH monitoring system. Animals: Six healthy adult mixed-breed colony dogs. Methods: Utilizing a randomized, 4-way cross over, open-label study, dogs were administered famotidine PO (1.0-1.3 mg/ kg q12h), omeprazole tablet (1.5-2.6 mg/kg q24h), omeprazole reformulated paste (RP) (Gastrogard, 1.5-2.6 mg/kg q24h), and placebo for 7 days followed by a 10-day washout period. Radiotelemetric pH capsules were placed with gastroscopy assistance to continuously record intragastric pH for 4 days (days 4-7 of dosing). The percentage of time that intragastric pH was !3 and !4 was compared among treatment groups using repeated measures of analysis of variance. Tukey's Studentized range test was used to determine which groups were different with a 5 0.05.Results: Mean AE SD percent time intragastric pH was !3 and !4 was 22 AE 8% and 14 AE 6% for famotidine, 63 AE 14% and 52 AE 17% for omeprazole tablet, 54 AE 17% and 44 AE 18% for omeprazole RP, and 6 AE 6% and 5 AE 5% for placebo. Both omeprazole formulations significantly increased intragastric pH compared with famotidine and placebo, but omeprazole tablet and RP was not significantly different from each other.Conclusion: Oral omeprazole tablet and RP provide superior gastric acid suppression to famotidine, and should therefore be considered more effective for the treatment of acid related disorders in dogs.

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Efficacy and safety of current trabeculectomy surgery Methods: 428 patients with OAG and no previous glaucoma surgery from 9 units were evaluated. All cases had 2 yr minimum follow up. Main outcomes: IOP, VA, complications and interventions. Reoperation for glaucoma (except needling and resuturing) and loss of light perception were classified as failures. Results: Antifibrotics were used in 400 (93%) cases; MMC in 271 (63%), 129 had 5‐FU (30%). At 2 years, IOP (mean ± SD) was 12.3 ± 4.3 mmHg, 370 (86%) had IOP ≤21 mmHg without medication; 405 (95%) achieved an IOP ≤ 21 mmHg overall. IOP ≤18 mm Hg was achieved by 352 (82%) without treatment and 373 (87%) overall. By TVT criteria: 310/365 (85%) had complete success at 2 yr and 335/365 (92%) achieved qualified success. Postoperative treatments: suture manipulation 43%, resuturing 5.1%, bleb needling 16%, postop 5FU 27% and cataract extraction in 31%. Visual loss of more than two lines occurred in 24 (5.6%). 31 (7.2%) had late hypotony (IOP <6 mmHg). 2 patients (0.5%) developed blebitis. One patient had endophthalmitis at 3 wks (0.2%). We show good trabeculectomy outcomes with low rates of complications can be achieved but intensive postoperative care is required.