Background: As individuals grow older, they may be more susceptible to chronic diseases, which can affect their overall health. Periodontitis, for instance, is one of the most common oral diseases that result from prolonged exposure to pathogens. The main etiology of periodontitis is dental biofilms, but several risk factors may also affect the progression of the disease. Purpose: The study aimed to determine whether there was an association between age, gender and education level and the severity of periodontitis using the 2017 American Academy of Periodontology (AAP) classification. Methods: A retrospective analytical study was used to determine the stage and grade of periodontitis in relation to age, gender and education level. Secondary data in the form of medical record status was analysed using software applications. Results: The distribution of periodontitis was 66.7% in pre-elderly patients (45–59 years), 61.5% in male subjects and 39.7% in individuals with middle education levels. Using chi-square analysis, the severity of periodontitis showed a statistically significant correlation with age (p=0.01) and gender (p=0.003). In contrast, the level of education was not statistically correlated to the severity of periodontitis (p=0.887). The percentage of stage IV grade B was highest in elderly patients (65.38%), while stage IV grade C was the highest in male subjects (41.67%). Conclusion: The study showed that age and gender significantly influenced the occurrence and severity of periodontitis, while education level showed the opposite.
Hydroxyapatite has been widely used as bone graft materials in periodontics. However, hydroxyapatite is still considered costly, and many of them are imported. Hydroxyapatite manufacturers from natural sources could be an affordable alternative for periodontal regeneration therapy. Pugilina cochlidium and Babylonia spirata, L are the natural sources with high calcium carbonate. The two clamshells are easily found in Indonesia but their usage is still limited as hydroxyapatite materials. This study aims to synthesize the hydroxyapatite with sol-gel method from Pugilina cochlidium and Babylonia spirata, L as bone graft materials candidates.
Periodontitis is one of most common oral disease. Chronic periodontitis is characterised by gingival inflamation, periodontal pocket, lost of attachment, and alveolar bone loss. Smoking is a risk factor of periodontal disease that has direct effect to periodontal tissue. Smoking prevalence in Indonesia during 2013 was about 56,7% among men and about 1,9% among women. Smoking modifies the periodontal microbial challenge and host cytokine levels. Some studies showed that smoker has greater alveolar bone loss than non-smoker, and teeth that have the greatest alveolar bone loss are incisor and followed by molar. The aim of this study is to know the upper incisor and upper molar alveolar bone loss differences between smoker and non-smoker patient with chronic periodontitis. The study’s samples are 92 chronic periodontitis statuses and 200 periapical radiographs that selected by purposive sampling techinque. This study will measure the distance between cementoenamel junction to alveolar bone crest, cementoenamel junction to tooth apex, and alveolar bone loss percentage at upper incisor and upper molar. To compare the differences upper incisor and upper molar alveolar bone loss at patient with chronic periodontitis between smoker and non-smoker will be analyzed by independent t test and Mann-Whitney U test. The result showed that smoker has greater alveolar bone loss than non-smoker. There is no significant differences at upper incisor alveolar bone loss and there is significant differences at upper molar alveolar bone loss between smoker and non-smoker patient with chronic periodontitis.
Chronic periodontitis is an inflammatory disease which is characterized by the absence of pain and develops slowly, loss of attachment and resorption of bones that causes teeth to mobile and loose. Some markers responsible for the inflammatory process include cytokines, such as Interleukin-6 (IL-6), as one of the inflammatory cytokines, plays an important role in the inflammatory response of the periodontium. To handle the case of periodontitis, can be done by scaling and root planning (SRP) and can be combined with systemic ingredients and the application of herbal ingredients. One of the natural ingredients that has been used in wound healing is binahong leaves. In this study using 3% binahong leaves gel extract was applied to subgingival to reduce levels of IL-6 and periodontal status. In this study, using 16 samples, were divided into 2 groups: ie 8 samples as a test group, and 8 samples as a control group. IL-6 levels were examined after scaling and root smoothing. Statistically, there was a significant decrease in IL-6 levels in the gingival sulcus fluid after scaling and root planing (SRP) in periodontitis patients with ap values <0.05. There was a significant decrease in measurement of IL-6 levels in the test and control groups after application of subgingival gel of binahong leaves extract (Andredera cordifolia (Ten.) Steenis) 3% in patients with chronic periodontitis. there was a significant decrease in IL-6 levels in the gingival sulcus fluid after scaling and root planing (SRP) in periodontitis patients with ap value <0.05.
Periodontitis is typically associated with disorders characterized by compromised tooth-supporting tissue. Damage to periodontal tissue is caused by an imbalance between matrix metalloproteinases and their inhibitors. Decreased tissue inhibitor and elevated matrix metalloproteinase levels result in collagen connective tissue and bone degradation. Several studies have shown that high levels of matrix metalloproteinase-13 (MMP-13) and low levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) are also found in gingival crevicular fluid and saliva of patients with periodontitis. The purpose of this study was to determine the comparison of MMP-13 levels, TIMP-1 levels of saliva and bone density in patients with chronic periodontitis before and after scaling and root planning (SRP). The study samples were selected from patients who came for treatment at the Periodontics Installation of Universitas Sumatera Utara. A total of 16 patients were selected (n = 16) with a diagnosis of chronic periodontitis. The result showed that salivary MMP-13 levels in chronic periodontitis patients before SRP were higher than salivary MMP-13 levels after SRP and the difference was statistically significant (p < 0.05). It was also revealed that salivary TIMP-1 levels and alveolar bone density in chronic periodontitis patients before SRP were lower than that after SRP and the difference was statisticallysignificant (p < 0.05). There was a positive correlation between clinical parameters and salivary MMP-13 levels in patients with chronic periodontitis before and after SRP, but it was not statistically significant (p > 0.05). There was a negative correlation between clinical parameters and salivary TIMP-1 levels in patients with chronic periodontitis before and after SRP, but it was not statistically significant (p > 0.05).
Coronary Heart Disease (CHD) is the major cause of death in most countries in the world. Gram-positive and Gram-negative bacteria have been identified in bacteremia cases and known to have a role in various vascular diseases, including Streptococcus sanguinis which is most frequently isolated from endocarditis patients and often associated with CHD. The purpose of this study was to analyze the number of Streptococcus sanguinis isolated from dental plaque and saliva of subjects with and without CHD. Bacterial colonies isolated from the dental plaque and saliva of 16 subjects without CHD and 8 subjects with CHD were planted in Mitis salivarius agar, and then the DNA was extracted and quantified with a Real-Time PCR technique using 16S rRNA specific primers. The quantification of Real-Time PCR showed that there was a difference in the number of S. sanguinis between the two groups of subjects, but an unpaired T-test showed that the difference was not statistically significant. Furthermore, the number of S. sanguinis from dental plaque in CHD subjects tends to be higher than that of non-CHD subjects whereas the number of S. sanguinis from saliva in non-CHD subjects tends to be higher than that of CHD subjects.
Gingivitis is an inflammation of the gingiva due to an accumulation of bacterial plaque that can cause periodontal structural damage. In general, to diagnose gingivitis involves clinical measurements and radiographic assessment which are often poorly tolerated by the patients and are also subjected to measurement errors. Some researchers have found that saliva provides an easily available, non-invasive diagnostic medium for a rapidly widening range of diseases and clinical situations saliva. The aim of this study is to determine the difference of salivary total protein levels in plaque induced gingivitis and healthy patients. This bivariate analytic study is a non-experimental study, with a cross sectional design. 30 samples of saliva were taken by purposive sampling method and divided into saliva of patients suffering from plaque induced gingivitis and saliva of healthy patients, as control. Gingivitis was measured using Papilla Bleeding Index (PBI) while the total protein level of saliva was measured using the Bradford Assay method. The results of this study indicated that there was a significant difference (p <0.05) in salivary total protein levels between the plaque induced gingivitis patients and healthy patients. Plaque induced gingivitis patients had high protein content with a mean value of 0.360 while the mean value of healthy patient was 0.108. Based on the results of the study it is concluded that there was an increase in protein level in saliva in plaque induced gingivitis patients.
Background: Andaliman (Zanthoxylum achantopodium DC) is an endemic plant that is found in the province of Sumatera Utara, Indonesia. It contains secondary metabolites, such as alkaloids, flavonoids, glycosides, saponins, tannins, and triterpenoids/steroids, which can potentially be used as a mouthwash. Streptococcus sanguinis and Staphylococcus aureus are the primary colonizing bacteria in plaque formation. Bacterial plaque is known to be the main cause of periodontal disease but can be controlled mechanically and chemically using mouthwash. Purpose: To determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of andaliman extract mouthwash (2%, 4%, 8%) against Streptococcus sanguinis ATCC®10556™ and Staphylococcus aureus ATCC® 25923™. Methods: This is a laboratory study with a post-test control-only design. The sample consists of andaliman extract mouthwash (2%, 4%, 8%), a positive control (chlorhexidine gluconate 0.2%), and a negative control (mouthwash formulation without andaliman extract) with three repetitions for each group. Data were analyzed with the one-way ANOVA test and post hoc LSD test. Results: The andaliman extract mouthwash with concentrations of 2%, 4%, and 8% significantly reduced the number of Streptococcus sanguinis and Staphylococcus aureus colonies (p<0.05), and there was a significant difference in the andaliman extract mouthwash with concentrations of 2%, 4%, and 8% compared to the negative control. Conclusion: Andaliman extract mouthwash with a concentration of 8% was more effective in inhibiting Streptococcus sanguinis growth than Staphylococcus aureus. The MIC values for both bacteria were 2%, but the study could not determine the MBC value.
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