Background: To examine the impact of pharmacist counseling and follow-up on patient’s medication compliance and Helicobacter Pylori (H. pylori) eradication and evaluate the efficiency of an eradication regimen consisting of Clarithromycin 500 mg, Amoxicillin 1 g, and Lansoprazole 30 mg, twice daily for 14 days. Methods: Two hundred patients undergoing endoscopy and positive rapid urease tests were included in the present study. Patients were randomly divided into two groups: an intervention group (n=100) and a control group (n=100). The intervention patients obtained their medications from the hospital pharmacist and received sufficient counseling and follow-up. On the other hand, the control patients received their medications from another hospital pharmacist and went through the routine hospital procedure without good counseling and follow-up. Results: The intervention resulted in a statistically significant improvement in outpatient compliance with medication (45.0% vs 27.5%; P<0.05) and eradication of H. pylori (28.5% vs 42.5%; P<0.05) among those patients. Conclusion: This study reflects the importance of pharmacist counseling and patient compliance to medication, as the patients who received pharmacist counseling exhibited perfect compliance to medication, which led to the successful eradication of H. pylori.
Objective: Statins are one of the most effective drugs for reducing cholesterol and triglyceride levels, which main activity includes inhibiting 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase that is involved in cholesterol synthesis. However, statins are associated with several side effects; the most commonly reported ones are those related to the liver. This study was conducted to compare the impact of two formulas of Atorvastatin: Atorvastatin calcium (ATV), and Nanoparticles of Atorvastatin (NATV) on the liver. Methods: thirty Albino rats were randomly divided into three groups; control group (n=10) (standard diet), Atorvastatin group (ATV) 40 mgkg group, and Nanoparticle Atorvastatin group (NATV) 40 mgkg. After 30 days, all rat groups were sacrificed. Results: In comparison with the control group, the ATV and NATV groups had a significant increase in the activities of liver enzymes alkaline phosphatase (ALP), aspartate transaminase (AST), and alanine transaminase (ALT) (p< 0.05). Compared with the ATV group, the NATV group had a significant increase in the activities of liver enzymes alkaline phosphatase (ALP), aspartate transaminase (AST), and alanine transaminase (ALT) (p< 0.05). Furthermore, the NATV group significantly reduced LDL, VLDL, TC, and TG compared to the control and ATV groups (p< 0.05). The histopathological examination showed hepatocyte necrosis and sinusoidal vessel congestion, which was more significant in the NATS group than in the ATV group. Conclusion: NATV can cause a significant increase in the level of liver enzymes and has a more histopathological effect on the liver than ATV.
BACKGROUND: The novel coronavirus outbreak (COVID-19) presented an opportunity to conduct an online survey to research the psychological fatigue as a mental health issue among the students of Jadara University, Jordan. AIM: This study aimed at assessing prevalence of fatigue in the student population of Jadara University (Irbid, Jordan) and its association with COVID-19 quarantine. METHODOLOGY: A cross-sectional study was conducted in Jadara University during a period of 2 months, extending from March to May, 2020. Two-hundred students (43.8% males and 56.2% females) participated in the study and filled forms of the fatigue assessment scale. RESULTS: Psychologically-tired students constituted 59.0% of the participants whereas the remainder participants were normal students. Moreover, statistically-significant differences in fatigue between students of the various academic years (p = 0.04) were found. The highest proportion of students suffering from fatigue was observed in the fourth-, and 5th-year students (21 out of 42 and 9 out of 18, respectively, [i.e., 50.0%, each]). The lowest proportion of students suffering from fatigue was that of the 1st-year students (29.0%). Significant differences in fatigue were also found between working and non-working students (p = 0.001), where all the non-working students (92; 100.0%) suffered from fatigue while most of the working students experienced no fatigue (82; 69.0% of the working students). CONCLUSION: The current study adds to the growing body of knowledge available to policymakers and mental health practitioners throughout the world about the links between individual mental health and the COVİD-19 quarantine.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.