The Positive Impact of Patient’s Knowledge on Medication Adherence Among <i>Helicobacter pylori</i> Infected Outpatients

Shoiab, Aiman A; Aziz, Noorizan Abd; Hassan, Yahaya; Alefan, Qais

doi:10.1166/asl.2018.12896

Cited by 2 publications

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“…Compliance among patients with chronic diseases is often lower than that among those with acute diseases ( Osterberg and Blaschke, 2005 ). Although H. pylori infection is not a chronic disease and the treatment duration does not exceed 2 weeks, poor compliance strongly impacts the eradication rate ( Shoiab et al, 2018 ). High compliance is defined as >90% intake of the prescribed dose.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori antibiotic resistance profile in Chinese children with upper gastrointestinal symptoms and a literature review for developing personalized eradicating strategies

Zhou,

Wang,

et al. 2024

Front. Pharmacol.

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Background:H. pylori (Helicobacter pylori) infections typically occur in early childhood. Although the prevalence of H. pylori in children is lower than that in adults, the eradication rate of this infection in children is relatively low because of resistance. In this study, we analyzed personalized treatment strategies to achieve treatment goals based on H. pylori resistance characteristics. This retrospective single-center study was conducted between January 2019 and December 2022 and enrolled 1,587 children who presented with upper gastrointestinal symptoms and underwent endoscopy. H. pylori culturing and antimicrobial susceptibility testing were performed.Results: Culture-positive results for H. pylori were obtained in 535 children. The resistance rates to clarithromycin (CLA), metronidazole (MET), and levofloxacin (LEV) were 39.8%, 78.1%, and 20.2%, respectively. None of the isolates were resistant to tetracycline (TET), amoxicillin (AMO), or furazolidone (FZD). Double resistance rates to CLA + MET, CLA + LEV, and MET + LEV were 19.1%, 3.0%, and 5.8%, respectively. Notably, triple-resistant to CLA + MET + LEV was 9.7%. Based on susceptibility tests, individualized triple therapy [proton pump inhibitor (PPI) +AMO + CLA/MET] was selected for 380 children with H. pylori sensitive to MET and/or CLA. In 155 children resistant to CLA and MET, bismuth-based quadruple therapy was recommended; for unable to receive bismuth, concomitant therapy was recommended for 14 children (<8 years of age); triple therapy with TET was recommended for 141 children (>8 years of age), with 43 children (>14 years of age) requiring FZD rather than TET.Conclusion: Resistance to H. pylori in Chinese children was relatively poor. Personalized therapy regimens should be based on susceptibility tests and avoided factors associated with treatment failure.

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori antibiotic resistance profile in Chinese children with upper gastrointestinal symptoms and a literature review for developing personalized eradicating strategies

Zhou,

Wang,

et al. 2024

Front. Pharmacol.

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“…Pharmacists profoundly influence patients' compliance with medication through the provision of proper counseling. However, counseling ought to be synchronized with the therapy prescribed, as the patients require a comprehensive explanation that covers the rationale behind the treatment and the probable side effects of the drug, which they may encounter during the therapyv (6,7) . The growing prevalence of H. pylori was associated with low eradication percentages, which raised the demand for investigating the effect of pharmacist counseling on the patient's compliance with medication and the rate of eradication of H. pylori (7,8) .…”

Section: Introductionmentioning

confidence: 99%

“…However, counseling ought to be synchronized with the therapy prescribed, as the patients require a comprehensive explanation that covers the rationale behind the treatment and the probable side effects of the drug, which they may encounter during the therapyv (6,7) . The growing prevalence of H. pylori was associated with low eradication percentages, which raised the demand for investigating the effect of pharmacist counseling on the patient's compliance with medication and the rate of eradication of H. pylori (7,8) . The present study is the first to be implemented in Jordan to improve patient compliance with medication and eradication of H. pylori infection (9) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Pharmacist Counseling on Patient Medication Compliance and Helicobacter Pylori Eradication Among Jordanian Outpatients

Shoiab

Alsarhan

Khashroum

2023

Arq. Gastroenterol.

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Background: To examine the impact of pharmacist counseling and follow-up on patient’s medication compliance and Helicobacter Pylori (H. pylori) eradication and evaluate the efficiency of an eradication regimen consisting of Clarithromycin 500 mg, Amoxicillin 1 g, and Lansoprazole 30 mg, twice daily for 14 days. Methods: Two hundred patients undergoing endoscopy and positive rapid urease tests were included in the present study. Patients were randomly divided into two groups: an intervention group (n=100) and a control group (n=100). The intervention patients obtained their medications from the hospital pharmacist and received sufficient counseling and follow-up. On the other hand, the control patients received their medications from another hospital pharmacist and went through the routine hospital procedure without good counseling and follow-up. Results: The intervention resulted in a statistically significant improvement in outpatient compliance with medication (45.0% vs 27.5%; P<0.05) and eradication of H. pylori (28.5% vs 42.5%; P<0.05) among those patients. Conclusion: This study reflects the importance of pharmacist counseling and patient compliance to medication, as the patients who received pharmacist counseling exhibited perfect compliance to medication, which led to the successful eradication of H. pylori.

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The Positive Impact of Patient’s Knowledge on Medication Adherence Among Helicobacter pylori Infected Outpatients

Cited by 2 publications

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Helicobacter pylori antibiotic resistance profile in Chinese children with upper gastrointestinal symptoms and a literature review for developing personalized eradicating strategies

Helicobacter pylori antibiotic resistance profile in Chinese children with upper gastrointestinal symptoms and a literature review for developing personalized eradicating strategies

Effect of Pharmacist Counseling on Patient Medication Compliance and Helicobacter Pylori Eradication Among Jordanian Outpatients

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