The rate of unmarried young women seeking repeated abortions was high in China on 2000. The rate of consistent condom use was low, and the rate of contraceptive failure was higher.
Some studies have shown that maternal per uoroalkylated substances (PFAS) exposure may be associated with low birth weight (LBW) of offspring. We conducted a meta-analysis to assess the association between maternal PFASs exposure and LBW in offspring. The researchers searched PubMed, Science Direct, Scopus, Google Scholar, Web of Science, and Embase to nd all the articles before October 2020. The Newcastle-Ottawa Scale was used to evaluate the quality of the studies. Finally, six articles were included for meta-analysis. Our meta-analysis showed were no signi cant correlation between maternal per uorooctanoic acid (PFOA) exposure and LBW of offspring: odds ratio (OR) = 0.90, 95% con dence interval (95% CI) = 0.80-1.01, with low heterogeneity (I 2 = 18.4%, P = 0.289); there was a signi cant positive correlation between maternal per uorooctane sulfonate (PFOS) exposure and LBW of offspring (OR = 1.32, 95% CI = 1.09-1.55) with no heterogeneity (I 2 = 0.00%, P = 0.570). The grouping analysis of PFOS showed was a signi cant positive correlation between maternal PFOS exposure and LBW of offspring in America (OR = 1.44, 95% CI = 1.15-1.72). This study provided a systematic review and meta-analysis evidence for the relationship between maternal PFASs exposure and LBW of offspring through a small number of studies. Researchers should conduct further studies between different regions.
Some studies have shown that maternal exposure to per uoroalkyl substances (PFASs) may be associated with early attention de cit hyperactivity disorder (ADHD) in children. The purpose of this systematic review and meta-analysis is to verify this association by reviewing existing studies and to provide a strong basis for preventing ADHD. The researchers searched electronic databases such as PubMed, Science Direct, Scopus, Google Scholar, Web of Science, and Embase for all studies published before October 2020. Finally, we included nine articles for analysis. Our meta-analysis showed that maternal exposure to PFASs was not signi cantly associated with the prevalence rate of early childhood ADHD (per uorooctanoic acid (PFOA): odds ratio (OR) = 1.00, 95%
Some studies have shown that maternal exposure to perfluoroalkyl substances (PFASs) may be associated with early attention deficit hyperactivity disorder (ADHD) in children. The purpose of this systematic review and meta-analysis is to verify this association by reviewing existing studies and to provide a strong basis for preventing ADHD. The researchers searched electronic databases such as PubMed, Science Direct, Scopus, Google Scholar, Web of Science, and Embase for all studies published before October 2020. Finally, we included nine articles for analysis. Our meta-analysis showed that maternal exposure to PFASs was not significantly associated with the prevalence rate of early childhood ADHD (perfluorooctanoic acid (PFOA): odds ratio (OR) = 1.00, 95% confidence interval (95% CI) = 0.75–1.25; perfluorooctane sulfonate (PFOS): OR = 1.01, 95% CI = 0.88–1.14; perfluorohexane sulfonate (PFHxS): OR = 1.08, 95% CI = 0.80–1.09; perfluorononanoic acid (PFNA): OR = 1.13, 95% CI = 0.99–1.28; perfluorodecanoic acid (PFDA): OR = 1.23, 95% CI = 0.15–2.32). Due to significant heterogeneity, we subsequently performed subgroup analysis and sensitivity analysis. In conclusion, a causal relationship between maternal PFASs exposure and ADHD in children was unlikely. Among them, PFOS, PFNA and ADHD might have positive associations worthy of further investigation.
Some studies have shown that maternal perfluoroalkylated substances (PFAS) exposure may be associated with low birth weight (LBW) of offspring. We conducted a meta-analysis to assess the association between maternal PFASs exposure and LBW in offspring. The researchers searched PubMed, Science Direct, Scopus, Google Scholar, Web of Science, and Embase to find all the articles before October 2020. The Newcastle-Ottawa Scale was used to evaluate the quality of the studies. Finally, six articles were included for meta-analysis. Our meta-analysis showed were no significant correlation between maternal perfluorooctanoic acid (PFOA) exposure and LBW of offspring: odds ratio (OR) = 0.90, 95% confidence interval (95% CI) = 0.80–1.01, with low heterogeneity (I2 = 18.4%, P = 0.289); there was a significant positive correlation between maternal perfluorooctane sulfonate (PFOS) exposure and LBW of offspring (OR = 1.32, 95% CI = 1.09–1.55) with no heterogeneity (I2 = 0.00%, P = 0.570). The grouping analysis of PFOS showed was a significant positive correlation between maternal PFOS exposure and LBW of offspring in America (OR = 1.44, 95% CI = 1.15–1.72). This study provided a systematic review and meta-analysis evidence for the relationship between maternal PFASs exposure and LBW of offspring through a small number of studies. Researchers should conduct further studies between different regions.
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