The relationship between maternal perfluoroalkylated substances exposure and low birth weight of offspring: a systematic review and meta-analysis

Abstract

Some studies have shown that maternal per uoroalkylated substances (PFAS) exposure may be associated with low birth weight (LBW) of offspring. We conducted a meta-analysis to assess the association between maternal PFASs exposure and LBW in offspring. The researchers searched PubMed, Science Direct, Scopus, Google Scholar, Web of Science, and Embase to nd all the articles before October 2020. The Newcastle-Ottawa Scale was used to evaluate the quality of the studies. Finally, six articles were included for meta-analysis. Our meta-analysis showed were no signi cant correlation between maternal per uorooctanoic acid (PFOA) exposure and LBW of offspring: odds ratio (OR) = 0.90, 95% con dence interval (95% CI) = 0.80-1.01, with low heterogeneity (I 2 = 18.4%, P = 0.289); there was a signi cant positive correlation between maternal per uorooctane sulfonate (PFOS) exposure and LBW of offspring (OR = 1.32, 95% CI = 1.09-1.55) with no heterogeneity (I 2 = 0.00%, P = 0.570). The grouping analysis of PFOS showed was a signi cant positive correlation between maternal PFOS exposure and LBW of offspring in America (OR = 1.44, 95% CI = 1.15-1.72). This study provided a systematic review and meta-analysis evidence for the relationship between maternal PFASs exposure and LBW of offspring through a small number of studies. Researchers should conduct further studies between different regions.

Obesity II: Establishing causal links between chemical exposures and obesity

“…Low birth weight is the most consistent outcome reported from gestational PFOA exposures in humans. A systematic review of infants born to mothers with higher pregnancy serum concentrations of PFOA linked exposure with lower birth weight [547] or that PFOA or PFOS exposure led to low birth weight [548] and lowered adiposity at birth [549,550]. Low birth weight is associated with increased weight gain later in life.…”

Fetal Glucocorticoid Mediates the Association between Prenatal Per- and Polyfluoroalkyl Substance Exposure and Neonatal Growth Index: Evidence from a Birth Cohort Study

“…PFASs could cross the placenta and can be a threat to fetal health. ,, Numerous literature have reported that prenatal PFAS exposure is associated with adverse outcomes. For example, PFOS exposure was significantly associated with low BW (6 studies, n = 17,128 (59 ∼ 4561), OR = 1.32, 95% CI: 1.09, 1.55) and preterm birth (21 studies, n = 28,765 (252 ∼ 11,737), OR = 1.20, 95% CI: 1.04, 1.38; 29 studies, n = 32,905 (252 ∼ 3535), OR = 1.01, 95% CI: 1.00, 1.02). As stated in the latest systematic review, most studies found that PFASs were negatively associated with BW, HC, BL, and PI .…”

“…We also applied grouped weighted quantile sum (GWQS) regression models to assess the joint effects of the alternative and legacy PFAS mixture using the GWQS package of R version. We categorized the 14 The models are adjusted for maternal age, pre-BMI, family income, environmental tobacco exposure during pregnancy, infant gender, and gestational age. b Ponderal index, the ratio of birth weight to birth length 3 .…”

Human Evidence of Perfluorooctanoic Acid (PFOA) Exposure on Hepatic Disease: A Systematic Review and Meta-Analysis

“…However, there are relatively few studies on the effects of PFOA exposure on hepatotoxicity and hepatic disease than other diseases. Most of the meta-analysis studies related to PFOA exposure are regarding reproductive and developmental toxicity [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ] and cardiovascular disease [ 27 ]. It is difficult to find a meta-analysis study on hepatotoxicity and hepatic disease.…”