Melissa officinalis L. (Lamiaceae) had been reported in traditional Moroccan medicine to exhibit calming, antispasmodic, and strengthening heart effects. Therefore, this study is aimed at determining the anti-inflammatory activities of M. officinalis L. leaves. The effect of the essential oil of the leaves of this plant was investigated for anti-inflammatory properties by using carrageenan and experimental trauma-induced hind paw edema in rats. The essential oil extracted from leaves by hydrodistillation was characterized by means of gas chromatography-mass spectrometry (GC-MS). M. officinalis contained Nerol (30.44%), Citral (27.03%), Isopulegol (22.02%), Caryophyllene (2.29%), Caryophyllene oxide (1.24%), and Citronella (1.06%). Anti-inflammatory properties of oral administration of essential oil at the doses of 200, 400 mg/kg p.o., respectively, showed significant reduction and inhibition of edema with 61.76% and 70.58%, respectively, (P < 0.001) induced by carrageenan at 6 h when compared with control and standard drug (Indomethacin). On experimental trauma, M. officinalis L. essential oil showed pronounced reduction and inhibition of edema induced by carrageenan at 6 h at 200 and 400 mg/kg with 91.66% and 94.44%, respectively (P < 0.001). We can conclude that the essential oil of M. officinalis L. possesses potential anti-inflammatory activities, supporting the traditional application of this plant in treating various diseases associated with inflammation and pain.

No abstract

No abstract

No abstract

No abstract

La synthèse et l'étude de la réactivité de la 4-phényl-1,5-benzodiazépin-2-one nous a permis d'obtenir deux dérivés : la 4-phényl-1,3,4,5-tétrahydro-1,5-benzodiazépin-2-one et la 4-phényl-1,5-benzodiazépin-2thiole. Ces produits ont fait l'objet d'une étude toxicologique et nous avons aussi exploré leur activité sur le système nerveux central, notamment l'action analgésique, grâce à un test spécifique. Après analyse de nos résultats, nous avons constaté que les composés testés s'avèrent atoxiques à des doses thérapeutiques, avec une DL 50 supérieure à 1000 mg/kg par voie intrapéritonéale, et exercent une action analgésique modérée, surtout pour les composés 1 et 3 vis-à-vis de l'acide acétylsalicylique. Le produit 2 a une action analgésique moins importante.

No abstract

No abstract