Extraction and psychotropic activity of the essential oil of verbena Lippia citriodora

Makram, Sanaa; Alaoui, Katim; Benabboyha, T.; Faridi, Bouchra; Cherrah, Yahia; Zellou, Ahmed

doi:10.1007/s10298-015-0935-1

Cited by 7 publications

(7 citation statements)

References 4 publications

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“…Lippia citriodora is traditionally used in Morocco for its muscle relaxant properties, sedatives, antipyretic, anti-asthmatic and antispasmodic, in case of digestive troubles, measles and headache (Pascual et al, 2001;Mojab and Yamouhammadi 2002;Manenzhe 2004), this species also works against respiratory disease (Benarba, 2015). Moreover, it is used to reduce nervousness and helps with sleeping especially with infants (Makram 2015).…”

Section: The Medicinal Plants and Therapeutic Treatmentsmentioning

confidence: 99%

“…Among 80% of the world's population, 4 billion people prefer healing with medicinal plants in which we actually find more than half of the medicines containing plants extract (Ghaemi 2007). This enables aromatic plants of being a huge potential for health, but which stay not really exploited (Makram 2015). The AMPs have a considerable asset due to the progressive discovery of the applications of their essential oils in health care as well as their use in other domains of economic interest.…”

Section: Introductionmentioning

confidence: 99%

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Ethnopharmacological survey of aromatic and medicinal plants of the pharmacopoeia of northern Morocco

Labiad¹,

Ettahir

Ghanmi³

et al. 2020

Eth Res Appl

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Backgound: For centuries, Moroccan herbalists have been using traditional plant-based medicines; however, most of these traditional healers misuse their use because of the limited information about harmful side effects. The traditional healers prescribe recipes that do not comply with any quality standards. Materials and methods:This study was designed and initiated in an effort to classify and shortlist the most reported medicinal plants used by traditional healers in the northern part of Morocco and identify their associated toxicities. Data from this work was obtained by collecting semi-interviews and direct questionnaires from local traditional healers and guided fieldtrips with herbalists.Results: A total of 40 of the identified plant species belonged to 34 genera and 21 botanical families. The most represented were Lamiaceace (13 species) followed by Asteraceace (6 species) and Cupressaceae (3 species). The most frequently cited and used species were Mentha pulegium (22.5%) and Rosmarinus officinalis (15%). In addition, our survey revealed 11 recipes prepared from 40 species. Leaves were the most used parts with a percentage of 30.52% and the main preparation method was infusion (63%). It shows that these recipes are generally administered orally during seven, fifteen or even thirty days with an average of one to three cups a day. Some of these recipes are used to treat diseases of the digestive and nervous system. The local population, whose purchasing power is very low, uses the plants harvested directly in the study area causing the disappearance of the most vulnerable species.Conclusions: This study shows that traditional medicine is still used and constituted a very rich heritage in northern Morocco. Further investigation of the benefits and risks of these plants will be needed to guide ancestral knowledge during selfmedication that causes negative effects on human health and will be needs planned exploitation.

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Section: The Medicinal Plants and Therapeutic Treatmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological survey of aromatic and medicinal plants of the pharmacopoeia of northern Morocco

Labiad¹,

Ettahir

Ghanmi³

et al. 2020

Eth Res Appl

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“…Lemon verbena is a medicinal plant exerting important biological activities such as antidepressant, antioxidant, sleep-promoting and analgesic effects [24,49,50,51]. The molecular mechanisms underlying these effects are still unknown.…”

Section: Discussionmentioning

confidence: 99%

“…In 2017, Razavi et al reported the anti-anxiety and muscle relaxant effects of VEE and Vs in vivo [17]. Another study showed induction of relaxation in mice and rats treated with essential oil extracted from the aerial part of verbena [50]. Accordingly, the aqueous extract of this plant was found to have a sedative effect in rats at high doses (700 and 1000 mg/Kg body weight of extract) [8].…”

Section: Discussionmentioning

confidence: 99%

Elucidation of the Molecular Mechanism Underlying Lippia citriodora(Lim.)-Induced Relaxation and Anti-Depression

Sabti

Sasaki

Gadhi

et al. 2019

IJMS

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Lippia citriodora ethanolic extract (VEE) and verbascoside (Vs), a phenypropanoid glycoside, have been demonstrated to exert relaxant and anxiolytic properties. However, the molecular mechanisms behind their effects are still unclear. In this work, we studied the effects and action mechanisms of VEE and Vs in vivo and in vitro, on human neurotypic SH-SY5Y cells.TST was conducted on mice treated orally with VEE (25, 50 and 100 mg/Kg), Vs (2.5 and 5 mg/Kg), Bupropion (20 mg/Kg) and Milli-Q water. Higher dose of VEE-treated mice showed an increase of immobility time compared to control groups, indicating an induction of relaxation. This effect was found to be induced by regulation of genes playing key roles in calcium homeostasis (calcium channels), cyclic AMP (cAMP) production and energy metabolism. On the other hand, low doses of VEE and Vs showed an antidepressant-like effect and was confirmed by serotonin, noradrenalin, dopamine and BDNF expressions. Finally, VEE and Vsenhancedcell viability, mitochondrial activity and calcium uptake in vitro confirming in vivo findings. Our results showed induction of relaxation and antidepressant-like effects depending on the administered dose of VEE and Vs, through modulation of cAMP and calcium.

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“…Aloysia citriodora is traditionally used in France as a sedative and muscle relaxant for newborns (Makram et al 2015). This species is native to South America and has been cultivated into Europe since 1784 (Pio Corrêa 1931).…”

Section: Graphic Proofmentioning

confidence: 99%

Medicinal plants for the "nerves": a review of ethnobotanical studies carried out in South Brazil

et al. 2019

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Among the medicinal purposes for which plants have been used is the treatment of "nerves". Th e objective of this study was to search for species of plants used in the state of Rio Grande do Sul (South Brazil) for the relief of symptoms related to central nervous system (CNS) disorders. Twenty-seven ethnobotanical studies were compiled, in which a total of 94 species were cited. Th e fi ve most cited species were Cymbopogon citratus (81.5 %), Melissa offi cinalis (77.7 %), Aloysia citriodora (66.6 %), Matricaria chamomilla (62.9 %) and Passifl ora edulis (51.8 %). Scientifi c studies have corroborated the popular use of these plants as sedatives, but most studies are preclinical and very few have been clinical (M. chamomilla and M. offi cinalis), and these were mainly exploratory or were performed against placebo. In addition to effi cacy data, there are also indications of toxicity for M. chamomilla and P. edulis. In conclusion, there is a great diversity of plant species used in the treatment of symptoms related to CNS disorders, and they are most frequently used as a sedative. Data indicate that M. offi cinalis possesses clinical effi cacy in the treatment of symptoms associated with anxiety without signs of toxicity.

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Extraction and psychotropic activity of the essential oil of verbena Lippia citriodora

Cited by 7 publications

References 4 publications

Ethnopharmacological survey of aromatic and medicinal plants of the pharmacopoeia of northern Morocco

Ethnopharmacological survey of aromatic and medicinal plants of the pharmacopoeia of northern Morocco

Elucidation of the Molecular Mechanism Underlying Lippia citriodora(Lim.)-Induced Relaxation and Anti-Depression

Medicinal plants for the "nerves": a review of ethnobotanical studies carried out in South Brazil

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