purpose: The aim of this study is to assess the effectiveness of maxillary cortical bone graft chips harvested by bone scraper, covered with platelet rich brin (PRF) in alveolar clefts Patients and methods: Seventy-two cleft patients were examined for their eligibility to be part in this comparative study, they were randomly divided into: group A, thirty-six patients had been received cancellous bone chips from iliac crest, group B, thirty-six had been received cortical bone chips harvested from maxilla using a curved bone scraper, covered with PRF.The clinical success over the follow-up period was evaluated on the basis of elimination of the oronasal stula, radiographic assessment of bone graft volume, achievement of the osseous continuity of the alveolar arch, and the extent of the vertical bone height. ResultsThe mean of volume gained in group A was (0.8053, +_ 0.9682), while for group B was (0.7397, +_ 0.7703). the amount of vertical bone loss between groups were registered, the chi-square test revealed insigni cant differences between study groups (P =0.547). the result of the frequency of stula development after grafting in both groups was insigni cant (p=0.074). Also, for the continuity of the maxilla as a one piece the results were insigni cant differences between study groups (p=0.058). Conclusion:In conclusion of our study, Intraoral harvesting of maxillary cortical chips by bone scraper covered with PRF is able to achieve a valid functional and aesthetic support in alveolar cleft patients, meeting the reconstructive goals.
purpose: The aim of this study is to assess the effectiveness of maxillary cortical bone graft chips harvested by bone scraper, covered with platelet rich fibrin (PRF) in alveolar cleftsPatients and methods: Seventy-two cleft patients were examined for their eligibility to be part in this comparative study, they were randomly divided into: group A, thirty-six patients had been received cancellous bone chips from iliac crest, group B, thirty-six had been received cortical bone chips harvested from maxilla using a curved bone scraper, covered with PRF.The clinical success over the follow-up period was evaluated on the basis of elimination of the oronasal fistula, radiographic assessment of bone graft volume, achievement of the osseous continuity of the alveolar arch, and the extent of the vertical bone height.Results The mean of volume gained in group A was (0.8053, +_ 0.9682), while for group B was (0.7397, +_ 0.7703). the amount of vertical bone loss between groups were registered, the chi-square test revealed insignificant differences between study groups (P =0.547). the result of the frequency of fistula development after grafting in both groups was insignificant (p=0.074). Also, for the continuity of the maxilla as a one piece the results were insignificant differences between study groups (p=0.058).Conclusion: In conclusion of our study, Intraoral harvesting of maxillary cortical chips by bone scraper covered with PRF is able to achieve a valid functional and aesthetic support in alveolar cleft patients, meeting the reconstructive goals.
BACKGROUND: Both benign and harmful head and neck disorders have been associated with the Epstein-Barr virus (EBV). Many studies have connected EBV to oral squamous cell carcinoma (OSCC). Oral squamous cell carcinoma is the most prevalent type of cancer. Fresh tissue samples from patients with OSCC were tested for the presence of Epstein-Barr virus. OBJECTIVE: To determine the frequency of EBV and IL10 expression in OSCC patients. MATERIALS AND METHODS: Fifty individuals with OSCC and 25 with clinically healthy oral mucosa were studied. In situ hybridization was used for the detection of EBV. Serum IL-10 levels were also evaluated in patients and controls using a human IL-10 ELISA Kit. RESULTS: EBV was detected in 4 healthy patients, 6 with moderately differentiated OSCC, 10 with poorly differentiated OSCC, and 19 with undifferentiated OSCC. These differences were statistically significant (p<0.05). IL-10 expression was more common in OSCC diagnostic groups than healthy controls, and the difference in blood IL-10 levels between patients and controls was statistically significant (p<0.01). CONCLUSION: The prevalence of EBV in OSCC suggests its possible role in oral cavity malignancy. On the other hand, IL-10 is expressed at higher levels in OSCC biopsies; such elevated concentrations may promote viral spread.
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