Background and Purpose: To detect sensitivity and specificity of diffusion-weighted imaging (DWI) as a non-invasive technique in detection of de-novo cases of cancer larynx. Patients and Methods: Patients included in this research were patients suspected of denovo cancer larynx; this study is a prospective randomized comparative clinical trial.
Results:The mean apparent diffusion coefficient (ADC) of laryngeal lesions (0.73± SD 0.23 x10-.3 mm2) was lower (p<0.001) than the mean of the normal part of the larynx in the same patients (1.09± SD 0.099 x 10-.3 mm2). The cut-off value of the ADC using receiver operating characteristics was >0.87 X 10-.3 mm2/s with the area under the curve (AUC) 0.979, with highly significant p-value >0.0001, with sensitivity 88.89% and specificity 100% and accuracy 94.45%, while conventional MRI show sensitivity of 83.33% and specificity 50% and accuracy of 66.66% with an insignificant p-value. Conclusion: DWI is an easily reproducible and non-invasive technique that can accurately explore the larynx and became a very important diagnostic tool of laryngeal diseases. This study demonstrated the cut-off point of ADC value for discrimination of malignant lesion is >0.87x 10-.3 mm2/s with restricted diffusion in DWI images.
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