Background
Ovarian cancer is the most lethal cancer in gynaecology. Surgery, chemotherapy, and radiotherapy are the most often used cancer-fighting strategies. Post-surgery infection is fairly prevalent, especially among people with insufficient immunity. Zinc oxide nanoparticles (ZnOnps) have amazing biomedical features as anticancer and antibacterial agents.
Methods
We investigated the behaviour of ZnOnps synthesized by green methods on ovarian cancers using established human ovarian cancer cell lines, besides the antibacterial action toward models of gram + ve and gram -ve bacteria. The cytotoxic effect of ZnOnps was calculated using a Sulforhodamine B (SRB) trial. Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were tested as models for gram + ve and gram -ve bacteria. The selected bacteria were subjected to concentrations of 20, 40, 80, and 100 μg/ml.
Results
The synthesized ZnOnps induced 50% inhibitory concentration (IC50) at a concentration of 27.45 μg/ml. The diameter of inhibition ranged between 20.16 ± 0.16 and 27 ± 0.57 mm for S. aureus and 25.66 ± 0.33 to 31 ± 0.33 mm for E. coli. ZnOnps antagonistic effect statistically differed with neomycin, cefaclor, and cefadroxil.
Conclusions
Green synthesis of ZnOnps is easily prepared, low cost, non-toxic, and eco-friendly. Their cytotoxic action on SKOV3 cells and their antibacterial characteristics pave the way to be an alternative therapy for ovarian cancer and S. aureus and E. coli infection.
Nearly all of the Egyptian hospitals are currently suffering from shortage in rare blood types (e.g., -AB, -B, +AB), which are needed to perform vital surgeries. This leads them (hospitals or doctors) to ask patients' relatives to donate the amount of the required blood. The alternative is that they are forced to pay for the blood if the required type and amount is already available in these hospitals or the blood banks. The main idea of this work is solving problems related to the blood banks from collecting blood from donators to distributing blood bags for interested hospitals. This system is developed in order to enhance the management, performance, and the quality of services for the management of blood banks, which will be positively reflected on many patients in hospitals. This chapter targets undergraduate students, academic researchers, development engineers, and course designers and instructors.
Background: Death as a result of pregnancy remains the chief cause of premature mortality worldwide. Placenta accreta spectrum (PAS) disorders have become a significant lifethreatening obstetrical issue due to their increased incidence. Placenta accreta and placenta previa are considered important causes of PPH. In 2007, Dawlatly and his colleagues described for the first time a simple technique of suturing an inverted lip of the cervix over the bleeding placental bed that was successful in controlling the bleeding and saving the patient's life. Our study was conducted to evaluate the impact of the cervical technique and discuss cervical changes after short-term follow-up of cases who were managed by this technique. Methods: Our study was conducted among a total of 140 pregnant women between June 2021 and July 2022. Follow up was done after 3 months for all participating women who were diagnosed with placenta previa or accreta. 70 cases who were diagnosed with placenta accreta and subjected to the cervical advancement technique, and 70 cases who were diagnosed with placenta previa and not subjected to cervical advancement technique at Minia University Mternity Hospital. Results: With a p-value of less than 0.05, the mean of the cervical length, the inner-to-inner diameter, the cervical shape and the position of the cervix show a statistically significant difference between the two included groups. Conclusion: cervix isn't abnormally affected in cases of placenta accreta when managed by the cervical advancement technique.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.