Zinc Oxide Nanoparticles Promise Anticancer and Antibacterial Activity in Ovarian Cancer

Abstract

Background Ovarian cancer is the most lethal cancer in gynaecology. Surgery, chemotherapy, and radiotherapy are the most often used cancer-fighting strategies. Post-surgery infection is fairly prevalent, especially among people with insufficient immunity. Zinc oxide nanoparticles (ZnOnps) have amazing biomedical features as anticancer and antibacterial agents. Methods We investigated the behaviour of ZnOnps synthesized by green methods on ovarian cancers using established human ovarian cancer cell lines, besides the antibacterial action toward models of gram + ve and gram -ve bacteria. The cytotoxic effect of ZnOnps was calculated using a Sulforhodamine B (SRB) trial. Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were tested as models for gram + ve and gram -ve bacteria. The selected bacteria were subjected to concentrations of 20, 40, 80, and 100 μg/ml. Results The synthesized ZnOnps induced 50% inhibitory concentration (IC50) at a concentration of 27.45 μg/ml. The diameter of inhibition ranged between 20.16 ± 0.16 and 27 ± 0.57 mm for S. aureus and 25.66 ± 0.33 to 31 ± 0.33 mm for E. coli. ZnOnps antagonistic effect statistically differed with neomycin, cefaclor, and cefadroxil. Conclusions Green synthesis of ZnOnps is easily prepared, low cost, non-toxic, and eco-friendly. Their cytotoxic action on SKOV3 cells and their antibacterial characteristics pave the way to be an alternative therapy for ovarian cancer and S. aureus and E. coli infection.

Biosynthesis of Artemisia abyssinica Leaf Extract-Mediated Bimetallic ZnO–CuO Nanoparticles: Antioxidant, Anticancer, and Molecular Docking Studies

“…However, due to their cost-effectiveness, structural activity, biocompatibility, and bioavailability, ZnO and CuO NPs have received special aspects among the various MO NPs in cancer and oxidative stress-induced ailments. , Owing to their surface crystal defects and semiconductive nature of these nanoparticles, the electrons move easily and could react with oxygen species to form free radicals, which in turn cause oxidative stress in cancerous cells. , Because of their inherent electrostatic nature and selective toxicity, ZnO NPs are more apposite in cancer therapy . ZnO nanoparticles have exhibited significant anticancer efficacies against a variety of cancer types, including lung cancer, breast cancer, ovarian cancer, and colorectal cancer . The anticancer potency of ZnO NPs is mainly through zinc-mediated protein activity disequilibrium and oxidative stress .…”

“… 16 , 17 Because of their inherent electrostatic nature and selective toxicity, ZnO NPs are more apposite in cancer therapy. 18 ZnO nanoparticles have exhibited significant anticancer efficacies against a variety of cancer types, including lung cancer, 19 breast cancer, 20 ovarian cancer, 21 and colorectal cancer. 22 The anticancer potency of ZnO NPs is mainly through zinc-mediated protein activity disequilibrium and oxidative stress.…”