No abstract

No abstract

This is the first report of the isolation of 7-O-p-coumaroylloganin from a gentianaceous plant, although the other glucosides, besides vogeloside, which is only known in the genus Halenia (3), are widely distributed in this family (4, 5).

Six new (1, 2, 6, 8, 13, and 20) and twenty previously isolated (3–5, 7, 9–12, 14–19, and 21–26) steroids featuring thirteen different carbocycle motifs were isolated from the organic extract of the soft coral Sinularia polydactyla collected from the Hurghada reef in the Red Sea. The structures and the relative configurations of the isolated natural products have been determined based on extensive analysis of their NMR and MS data. The cytotoxic, anti-inflammatory, anti-angiogenic, and neuroprotective activity of compounds 3–7, 9–12, 14–20, and 22–26, as well as their effect on androgen receptor-regulated transcription was evaluated in vitro in human tumor and non-cancerous cells. Steroids 22 and 23 showed significant cytotoxicity in the low micromolar range against the HeLa and MCF7 cancer cell lines, while migration of endothelial cells was inhibited by compounds 11, 12, 22, and 23 at 20 µM. The results of the androgen receptor (AR) reporter assay showed that compound 11 exhibited the strongest inhibition of AR at 10 µM, while it is noteworthy that steroids 10, 16, and 20 displayed increased inhibition of AR with decreasing concentrations. Additionally, compounds 11 and 23 showed neuroprotective activity on neuron-like SH-SY5Y cells.

Since prehistoric times, medicinal plants and their extracts had been used as prolific sources of medications. Pomegranate is a symbol of life, longevity and in Aurvedic medicine; pomegranate is considered a pharmacy up to itself. Despite several previous studies centered to the phytochemistry and pharmacological actions of all Punica granatum L. components, however, to date, few reports about the variety nana, which implies that this species is yet under-investigated. Punica granatum L. var. nana is a dwarf variety of Punica granatum popularly planted as an ornamental plant in gardens. This study aims to determining the biomedical potentiality of the methanolic extract of Punica granatum L. var. nana leaves as source of botanical hepatoprotective and hepatocurative agents. The methanolic extract exhibited hepatoprotective and curative effects against CCl 4 induced hepatotoxicity in rats and both effects were preventive and curative. The histopathological studies support the hepatoprotective and curative effects by restoring the normal tissue architecture. Furthermore, this extract was found to be safe by using experimental albino rats suggesting that it may be utilized as a potential source of some beneficial bioactive compounds.

The main objectives of this study were to detect the most appropriate random regression model (RRM) to fit the data of monthly egg production in 2 lines (selected and control) of Japanese quail and to test the consistency of different criteria of model choice. Data from 1,200 female Japanese quails for the first 5 months of egg production from 4 consecutive generations of an egg line selected for egg production in the first month (EP1) was analyzed. Eight RRMs with different orders of Legendre polynomials were compared to determine the proper model for analysis. All criteria of model choice suggested that the adequate model included the second-order Legendre polynomials for fixed effects, and the third-order for additive genetic effects and permanent environmental effects. Predictive ability of the best model was the highest among all models (ρ = 0.987). According to the best model fitted to the data, estimates of heritability were relatively low to moderate (0.10 to 0.17) showed a descending pattern from the first to the fifth month of production. A similar pattern was observed for permanent environmental effects with greater estimates in the first (0.36) and second (0.23) months of production than heritability estimates. Genetic correlations between separate production periods were higher (0.18 to 0.93) than their phenotypic counterparts (0.15 to 0.87). The superiority of the selected line over the control was observed through significant (P < 0.05) linear contrast estimates. Significant (P < 0.05) estimates of covariate effect (age at sexual maturity) showed a decreased pattern with greater impact on egg production in earlier ages (first and second months) than later ones. A methodology based on random regression animal models can be recommended for genetic evaluation of egg production in Japanese quail.

A total of 1180 1-day-old Japanese quail (Coturnix japonica) chicks were used to investigate the effect of feathering rates on growth and slaughter traits. Feathering rates were classified based on the results of stepwise regression using numbers and lengths of both primaries and secondaries and tail length at 7 and 10 days of age as predictors. At 7 and 10 days old, number of primary feathers had phenotypically positive low correlations (rps) with body weight (BW), whereas number of secondaries had positive medium rps with BW at different ages. Lengths of primary, secondary and tail feathers had highly positive rps with BW traits at different ages. Results of stepwise multiple regressions indicated that BW at 14, 21 and 28 days of age can be predicted using lengths of secondary and tail feathers at 10 days old, number of secondaries at 7 days old and length of secondaries at 7 days old, respectively. Body weight at 35 days of age can be predicted using number of primaries, lengths of secondaries and tail at 10 days of age and number of secondaries at 7 days of age. Higher BWs were obtained in the fast-feathering class from 21 up to 35 days of age than in other groups, whereas the slow-feathering class had the lowest BW. Significant class differences were found for carcass weight, feather weight and dressing% favouring the fast- over the slow-feathering class. Therefore, early feathering rates improved BW at later ages and slaughter traits in Japanese quail.

No abstract