The texture of the cryoglobulin was gelatinous 49:60(81.7 %) and flocculent 8: 60 (13.3 %). The mean of cryocrit percent among typhoid patients was 6.1 % while among control was 0.2 Cryoglobulin response was associated with RF in 28:57 (49.12 %) among typhoid patients sera and nil among controls. The immunofixation studies using radial immunodiffusion in gel have shown that type of cryoglobulin response was of mixed type IgG-IgM-IgA. The RF associated cryoglobulinemia have shown higher IgG concentration than non RF associated cryoglobulin. The Ig classes have shown individual variations .S.typhi O agglutinins were 46:57 (80.7 %) in typhoid. Thus , type IIIsecondary mixed IgG-IgM-IgA cryoglobulinemia associated with typhoid patients sera with S.typhi O specific cold agglutinins as well .
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