Mixed IgG, IgM and IgA Cryoglobulin Response in Human Typhoid Patients

Abstract

The texture of the cryoglobulin was gelatinous 49:60(81.7 %) and flocculent 8: 60 (13.3 %). The mean of cryocrit percent among typhoid patients was 6.1 % while among control was 0.2 Cryoglobulin response was associated with RF in 28:57 (49.12 %) among typhoid patients sera and nil among controls. The immunofixation studies using radial immunodiffusion in gel have shown that type of cryoglobulin response was of mixed type IgG-IgM-IgA. The RF associated cryoglobulinemia have shown higher IgG concentration than non RF associated cryoglobulin. The Ig classes have shown individual variations .S.typhi O agglutinins were 46:57 (80.7 %) in typhoid. Thus , type IIIsecondary mixed IgG-IgM-IgA cryoglobulinemia associated with typhoid patients sera with S.typhi O specific cold agglutinins as well .

The Functional Epitope Mapping of Vaccine

“…Typhoid vaccine functional epitope mapping showed specific normoglobulin, specific cryoglobulin inducing epitopes, allergenic, immunoprotective as well as lym phocyte mitogenic and blastogenic epitopes in the host reactive immune system. Though in compromised host immune system the host has shown quantitative decrease of epitope functions [8,9]. Brucella vaccine functional epitope mapping has shown specific cryoglobulin and specific normoglobulin inducing epitopes, allergenic epitopes, and granulomatogenic epitopes in reactive immune system.…”