This paper presents a comprehensive review of the principle and application of deep learning in retinal image analysis. Many eye diseases often lead to blindness in the absence of proper clinical diagnosis and medical treatment. For example, diabetic retinopathy (DR) is one such disease in which the retinal blood vessels of human eyes are damaged. The ophthalmologists diagnose DR based on their professional knowledge, that is labor intensive. With the advances in image processing and artificial intelligence, computer vision-based techniques have been applied rapidly and widely in the field of medical images analysis and are becoming a better way to advance ophthalmology in practice. Such approaches utilize accurate visual analysis to identify the abnormality of blood vessels with improved performance over manual procedures. More recently, machine learning, in particular, deep learning, has been successfully implemented in this area. In this paper, we focus on recent advances in deep learning methods for retinal image analysis. We review the related publications since 1982, which include more than 80 papers for retinal vessels detections in the research scope spanning from segmentation to classification. Although deep learning has been successfully implemented in other areas, we found only 17 papers so far focus on retinal blood vessel segmentation. This paper characterizes each deep learning based segmentation method as described in the literature. Analyzing along with the limitations and advantages of each method. In the end, we offer some recommendations for future improvement for retinal image analysis. INDEX TERMS Retinal colour fundus images, convolutional neural networks, retinal vessels segmentation.

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Since early 2020, the whole world has been facing the deadly and highly contagious disease named coronavirus disease (COVID-19) and the World Health Organization declared the pandemic on 11 March 2020. Over 23 million positive cases of COVID-19 have been reported till late August 2020. Medical images such as chest X-rays and Computed Tomography scans are becoming one of the main leading clinical diagnosis tools in fighting against COVID-19, underpinned by Artificial Intelligence based techniques, resulting in rapid decision-making in saving lives. This article provides an extensive review of AI-based methods to assist medical practitioners with comprehensive knowledge of the efficient AI-based methods for efficient COVID-19 diagnosis. Nearly all the reported methods so far along with their pros and cons as well as recommendations for improvements are discussed, including image acquisition, segmentation, classification, and follow-up diagnosis phases developed between 2019 and 2020. AI and machine learning technologies have boosted the accuracy of Covid-19 diagnosis, and most of the widely used deep learning methods have been implemented and worked well with a small amount of data for COVID-19 diagnosis. This review presents a detailed mythological analysis for the evaluation of AI-based methods used in the process of detecting COVID-19 from medical images. However, due to the quick outbreak of Covid-19, there are not many ground-truth datasets available for the communities. It is necessary to combine clinical experts’ observations and information from images to have a reliable and efficient COVID-19 diagnosis. This paper suggests that future research may focus on multi-modality based models as well as how to select the best model architecture where AI can introduce more intelligence to medical systems to capture the characteristics of diseases by learning from multi-modality data to obtain reliable results for COVID-19 diagnosis for timely treatment .

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