Nine known diterpene polyesters of segetanes, jatrophenes and paralianes have been isolated from the aerial parts of Euphorbia paralias L. The molluscicidal activity of isolated compounds was evaluated on Biomphalaria alexandrina (Ehrenberg). Paraliane diterpene, (2S,3S,4R,5R,6R,8R,12S,13S,14R,15R)-5,8,14-triacetoxy-3-benzoyloxy-15- hydroxy-9-oxo-paraliane, was the most potent compound against the snail. Anti-feedant activity was tested by a conventional leaf disc method against third-instar larvae of Spodoptera littoralis (Boisd). Jatrophene diterpene, (2R,3R,4S,5R,7S,8R,13R,15R)-2,3,5,7,15-pentaacetoxy-8-angeloyloxy-14,15- dioxojatropha-6(17)-11E-diene, had the highest anti-feedant activity among the compounds tested.