Assessment of reproductive toxicity of orally administered technical dimethoate in male mice

Farag, Ahmed A.; El-Aswad, Ahmed F.; Shaaban, N

doi:10.1016/j.reprotox.2006.12.003

Cited by 63 publications

(58 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the serum cholinesterase inhibition has been recommended due to acute toxicity of organophosphates results from the irreversible phosphorylation of the hydroxyl group located in the active site of the molecule (47) . These results are in accordance with those findings obtained by several authors (48)(49)(50)(51)(52) who concluded that ChE activity was significantly decreased after exposure of rats to organophosphorus pesticides. Table 7 shows the activities of serum ALT, AST and ALP as well as the levels of serum total protein and albumin as markers evaluate liver function in tested animals in different experimental groups.…”

Section: Toxicological Studies Effect On Cholinesterase Activitysupporting

confidence: 93%

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

2011

Egypt. J. Chem.

View full text Add to dashboard Cite

Section: Toxicological Studies Effect On Cholinesterase Activitysupporting

confidence: 93%

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

2011

Egypt. J. Chem.

View full text Add to dashboard Cite

“…The testis and epididymis homogenates were diluted with 1.5 mL of the same solution and spermatozoa and spermatids were counted at 400x in a hemocytometer. Five counts per sample were averaged [18] .…”

Section: Assessment Of Sperm Productionmentioning

confidence: 99%

Reproductive Toxicology of Tartrazine (FD and C Yellow No. 5) in Swiss Albino Mice

Mehedi¹,

Ainad-Tabet²,

Mokrane³

et al. 2009

American J. of Pharmacology and Toxicology

View full text Add to dashboard Cite

Abstract. Problem statement: Tartrazine (FD and C Yellow No. 5) is an orange-colored widely used in food products, drugs and cosmetics. This color has a potential toxicological risk. The current study evaluated the effect of sub-chronic consumption of tartrazine on the male reproductive system. Approach: Tartrazine was administered to adult male mice in drinking water at doses of 0, 0.1, 1 and 2.5% for 13 weeks. After that period, the weights of testes, epididymides and seminal vesicles were determined. Sperm counts in the testis and epididymides, motility, morphology and testis histology were assessed. Results: Body weight gain, absolute and relative testis, epididymis and seminal vesicles weights did not change. However, sperm count was decreased and sperm abnormalities were increased in the 2.5% tartrazine treated groups compared to the control. Sperm motility and histological changes in testis were observed in the middle and high treated groups. Conclusion/Recommendations: We concluded that excessive tartrazine consumption can have adverse effects on the male reproductive function. We suggested conducting surveys among the population to estimate their daily intake.

show abstract

“…Reproductive toxicity of this pesticide on adult rodents of both sexes have been demonstrated. Irregularities of Estrous cycle and altered level of serum gonadotrophins have been reported in females (Kaur and Dhanju, 2005;Mahadevaswami and Kaliwal, 2002), while impairment of fertility, suppressed libido, semen quality deterioration, altered testosterone levels and testicular degeneration are few of the reports available in males (Farag et al, 2007;Sayim, 2007;Ngoula et al, 2007a;2007b).…”

Section: Introductionmentioning

confidence: 99%

Effect of Dimethoate (An Organophosphate Insecticide) on the Reproductive System and Fertility of Adult Male Rat

Ngoula¹

2014

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dimethoate is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. In the present study, we investigated the effect of dimethoate (an organophosphate insecticide) on the reproductive system and fertility of male rats and the possible mechanism underlining its action. Twenty four adult Wistar male rats were divided into 4 groups of 6 animals per group and force-fed with 0, 3.66, 5.50 and 11 mg kg −1 body weight of dimethoate for 90 days. At 80 days of treatment, each males was allows to mate with two primiparous cyclic females. The results showed a significant decrease (p<0.05) of body weight gain in rats gavaged with dimethoate compared to control. In addition, this insecticide at the doses of 3.66, 5.5 and 11 mg kg −1 caused a significant (p<0.05) increase of the relative weight of epididymis. Dimethoate at its highest dose caused a decrease in the relative weights of testes and ventral prostate. The doses 3.66, 5.50 and 11.00 mg kg −1 body weight of dimethoate caused a significant decrease (p<0.05) of the sperm concentration and motility. The level of protein and cholesterol in the serum and testes as well as the activity of prostatic acid phosphatase decreased significantly (p<0.05) in rats treated with dimethoate compared to control. Fertility, gestation and parturition indices as well as the litter size decreased significantly in animals treated with 5.50 and 11.00 mg kg −1 body weight of dimethoate compared to control. The testicular histology of animals treated with high doses of dimethoate generally showed span of Sertoli cells destruction and disorganization of the germinal epithelium. The lumen of seminiferous tubules of treated rats was generally poor in sperm. The results of this study confirmed that dimethoate seriously deteriorate the male reproductive system resulting in decreased fertility.

show abstract

Assessment of reproductive toxicity of orally administered technical dimethoate in male mice

Cited by 63 publications

References 26 publications

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

Reproductive Toxicology of Tartrazine (FD and C Yellow No. 5) in Swiss Albino Mice

Effect of Dimethoate (An Organophosphate Insecticide) on the Reproductive System and Fertility of Adult Male Rat

Contact Info

Product

Resources

About