Background
Female pattern hair loss (FPHL) is a common non-scaring alopecia. Topical minoxidil is the only approved treatment for FPHL; however, it has frequent side effects. Ketoconazole is an antifungal with anti-androgenic properties.
Methods
The aim of this work was to evaluate the safety and possible trichogenic effects of ketoconazole in FPHL. Patients were randomly assigned into Group A with 20 patients who received 2% topical minoxidil solution and Group B involving 20 patients who were treated by 2% topical ketoconazole preparation. All patients were treated for 6 months and evaluated clinically plus via trichoscopy. Side effects were recorded, and patients’ satisfaction was measured.
Results
Regarding hair growth, a significant difference was detected between baseline and at 4th and 6th months in Group A. While in Group B, the improvement was delayed until the 6th month. Only 10% of Group B reported side effects. Patients’ satisfaction did not differ between the two groups.
Conclusions
Topical ketoconazole mediates a trichogenic effect in FPHL with few side effects. However, ketoconazole showed a delayed improvement versus minoxidil at similar concentrations. Further studies should evaluate the efficacy of higher concentrations of ketoconazole solutions for FPHL which is a promising therapy.
Trial registration
IRB approval status: reviewed and approved by IRB of Faculty of Medicine, Zagazig University; approval no. #3642
Background: Androgenetic alopecia (AGA) is an androgen-dependent, hereditary dermatological disorder , affecting men and women causing progressive thinning of the scalp hair in a defined Characteristic pattern, with significant negative impact on social and psychological state of patients. Aim of the work: To evaluate the efficacy and safety of Platelet Rich Plasma injection in androgenetic alopecia patients. Subjects and methods: A therapeutic trial study was carried out on a sample size of 20 patients with AGA who attended the outpatients' clinics of dermatology department -Zagazig University Hospitals. Results: At baseline, 16 patients (80%) had a positive pull test with a mean number of 9 hairs. At 4 th and 8 th week ,The hair loss decreased with a mean number of 5.5 and 3 hairs respectively . After PRP injection 2 patients (10%) achieved high improvement , 6 patients (30%) achieved moderate improvement , 6 patients (30%) achieved mild improvement and 6 patients (30%) achieved no change, with final patient's satisfaction (40%). Conclusion: PRP injection is relatively effective in treatment of Androgenetic alopecia.
Background: Female pattern hair loss is a common cause of alopecia in women that predominately affects postmenopausal women and is characterized by a decrease in hair density over the crown and frontal scalp. The aim of this study was a clinical and trichoscopic evaluation of topical minoxidil 2% solution in treatment of female pattern hair loss. Methods: A clinical trial was done with twenty patients with female pattern hair loss. The studied patients were treated with minoxidil 2% topical solution twice daily for six months. A clinical and trichoscopic examination were done before starting treatment and every two months with photo-documentation, and scoring of disease severity using Ludwig Scale. Results: Regarding hair growth, a significant difference was detected between baseline and both 4 and 6 months. 55% of studied patients reported side effects. Conclusion: Minoxidil stimulates hair growth after 4 months of treatment but with side effects as dermatitis and hypertrichosis.
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