Purpose of the research: This study was done to explore the ANA, RF and CRP in the patients with some of Rheumatic Symptoms Materials and methods:The studies were done for 103 patients with Rheumatic Symptoms and were included in this study and their sera tested for the presence of Antinuclear Antibody (ANA), Rheumatoid Factor (RF), and Creactive protein (CRP). Results:The results showed that 33% of the patients with Systemic Lupus Erythematosis (SLE) had+ve ANA, the remainder 67% of patients were with Rheumatoid Arthritis (RA), the incidence of SLE was 4: 1 female to male while of RA was 2: 1. The highest titers of ANA, RF, and CRP were in females. In the following age groups (10-14), (15-19) and (35-39) the incidence of SLE were in females only. No male or female with SLE in (40-44), (45-49) or (50-54).