BackgroundMetabolic syndrome (MetS) is a worldwide health problem, which is growing in Iranian adults. MetS is associated with risk of type 2 diabetes and coronary artery disease (CAD). In this study, we aimed to investigate the prevalence of MetS and its individual components in CAD patients.MethodsThis cross-sectional study was performed on 200 CAD patients who had undergone elective coronary angiography at the cardiology department. Anthropometric indices including waist circumference (WC) and body mass index were measured. Blood samples were obtained to determine glucose and lipid profile. MetS components were defined according to the modified Adult Treatment Panel III (ATP III) criteria.ResultsThe prevalence of MetS among patients was 49.5% (women: 55.9%; men: 40.2%; P < 0.05). The prevalence increased with age. The low high-density lipoprotein-cholesterol (low HDL-C) (84.8%), high fasting blood glucose (high FBG) (77.8%) and high WC (75.8%) were the most prevalent risk factors in CAD patients with MetS.ConclusionsRecent data indicate that the dyslipidemia, hyperglycemia and abdominal obesity are crucial predictors of MetS in CAD patients. Further prospective studies are recommended for more clarification.

BackgroundClinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases.ObjectiveThe aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD).MethodsIn a cross-sectional study, we assessed the levels of serum resistin and leptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests (AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls. Anthropometric measurements including weight and height for calculating of body mass index (BMI), and waist circumference (WC) were performed for evaluation of obesity.ResultsCAD patients had increased levels of leptin and CRP, (p < 0.001), cholesterol (p < 0.05), triglyceride (p < 0.01), and WC (p < 0.05) compared to healthy controls. There was no statistical difference between CAD and control subjects for resistin (p = 0.058). In a multiple regression analysis, only an association between serum leptin with BMI (β = 0.480, p < 0.05) and WC (β = 1.386, p < 0.05) was found.ConclusionsThe findings suggest that leptin is a better marker of fat mass value than resistin and may be considered an independent risk factor for cardiac disorders that is largely dependent on obesity. However, further prospective studies are needed to confirm these results.

Summary Growing evidence has demonstrated that oxidative stress and increased altered oxygen utilization contribute to atherogenesis and cardiovascular disease (CVD) progression. Antioxidants protect the body from damage caused by free radicals. The objective of this study was to determine antioxidants status in CVD patients. This cross-sectional study was performed on 71 patients clinically diagnosed with CVD and 63 healthy individuals. Plasma malondialdehyde (MDA) level was measured for lipid peroxidation product and erythrocyte SOD and GPx activities as enzymatic antioxidants. The serum levels of vitamins A and E were assayed using HPLC and vitamin C by the photometric method. Total antioxidant capacity (TAC) was measured using the ferric reducing ability of plasma (FRAP) method. The results showed a significant reduction in antioxidant status (enzymatic and non-enzymatic) with a concomitant increase in the concentrations of lipid peroxidation products in CVD patients. There was a significant inverse correlation among TAC, SOD, GPx and vitamin C with MDA. It can be concluded that the antioxidant defense system plays an important role in preventing the development and progression of CVD with the ability to control oxidative stress.

Background and aims:Obesity and hypertension are the major threats to health in a sedentary lifestyle and stressful jobs. The bank employees have sedentary jobs with high mental stress. The aim of this study was to determine the prevalence of hypertension and obesity and related factors among bank employees in Zahedan, located in Sistan and Baluchistan province, Iran. Methods: In this cross-sectional study, 350 employees aged 23 to 57 years were randomly selected out of 15 bank branches from December 2016 to February 2017. An information form including demographic data (i.e., age, education levels, experience years in the banking profession, and physical activity) was completed for each participant. Body mass index (BMI) was assessed for the determination of general obesity. In addition, waist circumference (WC) and waist-to-height ratio (WHtR) were measured for the evaluation of abdominal obesity. Two recordings of blood pressure (BP) were obtained in a sitting position. Finally, a multivariate logistic regression analysis was used to examine the independent predictors of hypertension. Results: The prevalence of pre-hypertension and hypertension were 33.1% and 61.1%, respectively. Further, the rates of overweight and obesity were 49.1% and 10.3%, respectively. Furthermore, elevated WC and high WHtR were 20.9% and 59.4%, respectively. Based on the results, the prevalence of obesity and hypertension increased significantly by aging. Conclusion: In general, the results of the study showed that the prevalence of overweight and hypertension among bank employees was high compared to the general population. Thus, periodic screening is recommended for an early determination of hypertension.

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