ABSTRAKPenambahan Bahan Kimia Obat (BKO) ke dalam jamu dapat membahayakan kesehatan penggunanya. Fenolftalein merupakan salah satu senyawa kimia yang berpotensi ditambahkan ke dalam jamu pelangsing karena sifat laksatifnya. Penelitian ini bertujuan menganalisis keberadaan fenolftalein pada lima jamu pelangsing lokal (A,B,C,D,E) dan lima jamu pelangsing impor (F,G,H,I,J). Pengujian meliputi: pemeriksaan keabsahan registrasi dan kemasan, analisis kualitatif dan kuatitatif fenolftalein. Analisis kualitatif dilakukan dengan reaksi warna menggunakan NaOH 0,1 N, membandingkan kromatogram hasil KCKT dan spektrum UV sampel dengan pembanding. Analisis kuantitatif dilakukan dengan spektrofotometri UV. Hasil penelusuran di situs BPOM dari kesepuluh sampel hanya sampel E yang teregistrasi. Hasil reaksi warna, analisis kromatogram dengan HPLC dan analisis dengan Spektrofotometri UV-visible menunjukkan bahwa sampel F positif mengandung fenolftalein dengan kadar 47,133±0,0058%. Penggunaan fenolftalein jangka panjang dapat memicu kanker dan menyebabkan mutasi pada DNA.Kata kunci : jamu pelangsing, fenolftalein, bahan kimia obat ABSTRACT The addition of chemicals compounds into herbal medicine may be harmful to the health of users. Phenolphthalein is one of the chemical compounds that potentially is added into the herbal slimming because it's laxative effect. This study aimed to analyze the presence of phenolphthalein in five local herbal slimming (A, B, C, D, E) and five import herbal slimming (F, G, H, I, J). The tests included
Sengkubak is a native plant to Southeast Asia which mainly grows in the Kalimantan and Sumatra Islands. The local community grows it as a natural flavour enhancer as historical heredity. This paper aims to find a deeper potential prospect, exploration, and preliminary testing of glutamic acid as a natural flavouring agent. This research used a hybrid approach through laboratory testing and literature studies related to user community information, economic prospects. The collecting process and drying were carried out at West Kalimantan Assessment Institute for Agricultural Technology, while extraction activities were carried out at ISMCRI. The glutamic acid analysis used Ultra Performance Liquid Chromatography (UPLC) at the Saraswanti Indogenetic laboratory. The results show that sengkubak has not been cultivated well and harvested wild. The yield value of the extract produced using water and ethanol solvent 96% were 21.23% and 17.43%, respectively. By water and ethanol solvent, the concentrated extract contained the glutamic acid 2,845.82 mg/kg and 1979.32 mg/kg, respectively. Further research is needed to create prototypes of derivative products from sengkubak extract with water solvent extracts to be used commercially.
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