Introduction. With the growth of urbanization processes, the problem of professional exposure to electric and magnetic fields of industrial frequency is an increasingly relevant topic. Recently, the scientists paid a special attention to the long-term health consequences associated with prolonged exposure to harmful physical factors. The previously obtained data on the increase in the levels of lipid metabolism and hormonal and metabolic disorders in workers exposed to electric and magnetic fields of industrial frequency determine the relevance of studying adipokine metabolism and assessing genetic risk factors for predisposition to cardiovascular pathology in employees of the electric power industry. The study aims to research the relationship of biochemical and molecular genetic markers of adipokine metabolism with indicators of hormonal and metabolic disorders for a comprehensive assessment of cardiovascular risk in workers exposed to electric and magnetic fields of industrial frequency. Materials and methods. The researchers examined 144 employees of the main group engaged in the repair and operation of power grid facilities and 40 employees of the control group who are not exposed to electromagnetic fields of industrial frequency.The concentration of leptin and adiponectin was determined in blood serum samples. The authors have calculated the ratio of adiponectin to leptin. We have performed a molecular genetic study of single nucleotide polymorphisms of leptin (LEP) G2548A (rs7799039), leptin receptor (LEPR) A668G (rs1137101) and adiponectin type two receptor (ADIPOR2) G795A (rs16928751) genes. Results. The staff of the main group revealed a higher level of leptin (8.1 (3.7; 14.4) ng/ml) relative to the same indicator in the control group (6.0 (4.1; 11.1) ng/ml), p<0.028. Levels of leptin and adiponectin moderately and weakly correlate with hormonal and metabolic parameters. In the group of employees with less than 10 years of experience, a higher level of adiponectin was established compared to the group with 11–20 years of experience (6.1 (4.6; 9.1) mcg/ml and 4.5 (3.6; 6.4) mcg/ml, respectively); with an increase in work experience of more than 20 years, a significant increase in the concentration of leptin was found (p<0.05). Scientists have identified the significance of single-nucleotide polymorphisms of the LEPR, LEP, ADIPOR2 genes in the development of abdominal obesity, an increase in cholesterol levels and a decrease in the level of total testosterone in workers exposed to electric and magnetic fields of industrial frequency. Limitations. The study is limited to the number of surveyed (144 employees). Conclusion. The results of the study indicate the relationship of biochemical and molecular genetic markers of adipokine metabolism with indicators of hormonal and metabolic disorders in employees exposed to electric and magnetic fields of industrial frequency. When examining workers exposed to electric and magnetic fields of industrial frequency, the use of clinical and laboratory markers of adipokine metabolism (biochemical, molecular genetic) is informative in a comprehensive assessment of cardiovascular risk. Ethics. The work complies with ethical standards developed in accordance with the Helsinki Declaration of the World Medical Association "Ethical Principles of conducting Scientific medical research with human participation" as amended in 2000 and the "Rules of Clinical Practice in the Russian Federation" approved by Order of the Ministry of Health of the Russian Federation No. 200n dated 01.04.2016. Informed consent to participate in the study was received from each of the surveyed, approved in accordance with the established procedure by the local ethics committee of Izmerov Research Institute of Occupational Health (minutes of the meeting of the Ethics committee of Izmerov Research Institute of Occupational Health No. 4 dated 12/25/2013).
Introduction. The safety of exposure to the population of a growing number of sources of electromagnetic fields everywhere, both in work and at home, has become a public health problem. This article presents the results of research on the study of the potentially adverse effects of electromagnetic fields of industrial frequency on the reproductive system of personnel of energy supply institutions. The aim of the study is to explore the possible adverse effects of electromagnetic fields of industrial frequency on the male reproductive system. Materials and methods. The object of the study was 144 employees engaged in the repair and operation of power grid facilities and 40 employees who are not exposed to electromagnetic fields of industrial frequency. To assess laboratory parameters, blood samples were taken, followed by determination of the levels of total testosterone, free testosterone and globulin binding sex hormones. Results. The subjects of the main group revealed a high incidence of prostatic hyperplasia and chronic prostatitis. The employees of the main group had lower concentrations of sex hormones (p<0.05) in relation to similar indicators of the control group. A negative correlation was revealed between the levels of total, free testosterone and sex hormone binding globulin with experience (r=-0.36 p=0.009; r=-0.264 p=0.06; r=-0.349 p=0.01, respectively). Limitations of the study. The study is limited by the number of highly trained workers exposed to electromagnetic fields of industrial frequency. Conclusions. The results of the study indicate the negative impact of electromagnetic fields of industrial frequency on the reproductive system of employees engaged in the repair and operation of power grid facilities. With an increase in the length of service of employees, a decrease in the concentration of globulin binding sex hormones, total and free testosterone was found. Among workers exposed to electromagnetic fields of industrial frequency, a high prevalence of prostate pathologies was revealed.
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