Dengue fever is the most common arthropod borne infection worldwide. Bacterial sepsis in dengue fever is not widely recognised. This is a retrospective cohort study of children who had sepsis coexisting along with Dengue fever. One hundred and twenty-four patients aged between three months and eighteen years admitted in two private hospitals in North India were studied. Thirteen children had concurrent sepsis (13/124, 10.4%). Children between 0 and five years (7/13, 53.8%, p = 0.019), having longer hospital stay (7/13, 53.8%, p = 0.00029), shock (10/13, 76.9%, p = 0.00001), and increased PCT (13/13, 100%, p < 0.001) were some indicators of sepsis in these patients. Blood cultures were positive in five children. It is a matter of speculation as to why these patients of dengue are more susceptible to sepsis. Increased vascular permeability may increase the chances of bacterial contamination. Antibiotics should not be used routinely in dengue fever. However, young children presenting with severe symptoms especially shock should be screened for sepsis, and appropriate antibiotics should be started early.
Acquired heart diseases (AHD) cause significant morbidity and mortality in children. There are limited studies on their burden in children. We conducted a retrospective study of 85 consecutive children diagnosed with AHD using clinical evaluation and echocardiography at Medical College, Kanpur, India to determine the aetiology and outcome of AHD in children. We found rheumatic heart disease (RHD) in one-third, cardiomyopathies or myocarditis combined in a further third and the remaining third were other causes, including pericardial diseases and metabolic or genetic disorders. These latter diseases were frequently misdiagnosed, causing significant morbidity and mortality. Hence, in children of all age groups presenting with unexplained shock, dyspnoea, hepatomegaly and ascites, cardiac status should be carefully and critically evaluated so that non-rheumatic AHD may not be missed.
Preventive measures are the best cure for any disease as they reduce the infection rate. Preventive measures are affected by knowledge, attitudes, and practices towards the disease. Therefore, this study aimed to assess the awareness, perceived risk, and protective behavior toward COVID-19 among undergraduate students of the Delhi and National Capital Region, India. An online questionnaire-based random survey was conducted amongst 605 undergraduate students to assess the demographic characteristics of participants, their level of awareness, perceived risk, and protective behavior regarding COVID-19. The overall awareness, perceived risk, and protective behavior for COVID-19 were found high in undergraduate students (0.000***,0.000***,0.000***). When variable (Gender, area of living, and subject studies) based analysis was performed among participants, a non-statistical significance difference was observed in total awareness among them (p>0.05) towards 0.121, 0.937). Whereas Female, urban, and science participants were found to perceive the risk for COVID-19 more accurately in comparison to male, rural and non-science participants in total perceive risk analysis (p= 0.016**, 0.035**, 0.036**). However, urban participants showed more Total protective behavior as compared to the rural participants (p=0.048**) and there was no statistical significance difference in protective behavior in terms of Male/Female and Science/ non-science participants (p=0.189, 0.100). These findings will contribute to the continued regional/ global efforts to better understand preventive crisis response to the COVID-19 pandemic. This study emphasizes the need for conducting periodic webinars for educational intervention for all college students which could be useful to create more awareness.
Post-malaria neurological syndrome(PMNS) is a rare heterogenous syndrome heralded by the appearance of new neurological or psychiatric manifestations emerging in the post-infectious phase after clearance of malaria parasitaemia. Most cases of PMNS have been described in adults. Only seven cases have been reported in children. We describe two further cases of possible PMNS who presented with prominent psychiatric manifestations evolving into generalized encephalopathy after complete recovery from malaria. Both patients were treated with antivirals and antibiotics without clinical improvement. One patient received pulse corticosteroids and had a remarkable and rapid clinical improvement. The other recovered without specific treatment.
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