Objective: To analyze effects of turmeric in glycemic control and insulin secretagogue activity in alloxan induced diabetic rat model. Study Design: Experimental Study. Setting: Department of Surgery, Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad. Period: February 2019 to January 2020. Material & Methods: A sample of 100 adult male rats was selected according to inclusion criteria. Rats were grouped as negative control (group A), positive control – diabetic rats (group B), and experimental groups C – E. Group C- was diabetic rat + 100 mg ethanol extract of turmeric, Group D- was diabetic rat + 300 mg ethanol extract of turmeric, and Group E- was diabetic rat + 500 mg ethanol extract of turmeric. Overnight fasting rats were administered Alloxan 120 mg/Kg body weight intraperitoneally (i.p) by pinching abdominal wall under skin for the induction of diabetes mellitus in the rats. Blood glucose, glycated hemoglobin A1 (A1C) and serum insulin were analyzed. Statistical analysis was performed on SPSS package (ver. 21.0, IBM, incorporation, USA) at p≤ 0.05 (Confidence interval 95%). Results: Blood glucose, A1C and serum Insulin levels were improved in turmeric treated experimental rats. Significant reduction in blood glucose and A1C were found in turmeric treated rats (P=0.0001). Serum insulin levels were found increased in turmeric treated experimental groups C – E compared to positive control B (P=0.0001). Conclusion: Administration of turmeric significantly reduced the blood glucose and A1C with increased serum insulin levels in alloxan induced diabetic rats.
Objective: To determine effects of Curcuma longa (CL) on the glycemic control, blood lipids and atherogenic index of plasma (AIP) in alloxan induced diabetic male Wistar albino rat model. Study Design: Experimental study. Setting: Department of Basic Medical Sciences, Suleman Roshan Medial College, Tando Adam, Sindh. Period: February 2019 to January 2021. Material & Methods: A sample of 100 rats was divided into negative controls (C-), positive (diabetic) control (C+), and experimental groups D, E and F. DM was induced by injecting Alloxan (120 mg/Kg body weight) intraperitoneally (i.p) to overnight fasting rats. Diabetic groups D, E, and F were treated with ethanol extract of Curcuma longa 100 mg, 300 mg and 500 mg orally daily for six weeks. Blood samples were collected for biochemical analysis. Atherogenic Index of Plasma (AIP) was calculated by log TAG/HDLc. Data analyzed on SPSS package (ver. 21.0, IBM, incorporation, USA) (p≤ 0.05). Results: Significant improvement in glycemic status and blood lipids was observed in Curcuma longa treated groups D, E and F (P=0.0001). Atherogenic index of plasma (AIP) in negative (C-) and positive (C+) control was 0.08±0.03 and 1.11 ±0.1 respectively (P=0.0001) that improved in Curcuma longa treated groups D, E and F noted as; 0.77±0.3, 0.68±0.3 and 0.62±0.4 respectively. Conclusion: Present study found ethanolic extract of Curcuma longa improves the glycemic control, lipid profile and atherogenic index of plasma (AIP) in alloxan induced diabetic rat model.
Objectives: To study the characteristic histological features of Portal gastropathy and its correlation with Child-Pugh Score in liver cirrhosis patients. Study Design: Cross sectional study. Place and Duration: Department of Anatomy and Gastroenterology Unit, Isra University Hospital from June to December 2012. Subjects and Methods: Gastric biopsies from 85 cases of liver cirrhosis with portal gastropathy were collected by non probabilityconvenient sampling. Olympus XQ 140 (version 3) was used for 2 mm thick tissue specimens by punch biopsy. Tissue pieces were preserved in 10% formalin. 3-5 μ thick tissue specimens were stained with H & E for microscopic examination. Results: Portal Gastropathy was noted in 91.7% of total study subjects. Gastric glands showed increase counts and increased size noted in 60.12% and 57.65% of cases respectively. Pyloric antrum revealed inflammatory cell infiltration of lamina propria. 95.2% inflammatory cells comprised of lymphocytes. Capillary congestion and edema was noted in 9.4% of cases. Spearman correlation showed positive correlation of Portal gastropathy and Child Pugh Class (CPC) score (R2=0.5244, p=0.0001).Conclusion: Portal Gastropathy was noted in 91.7%. Histological showed increase in size, length and count of gastric glands, capillary congestion and inflammatory cell infiltration. Spearman correlation showed positive correlation of Portal gastropathy and Child Pugh Class (CPC) score (R2=0.5244, p=0.0001).
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