Following injury, the oral mucosa undergoes complex sequences of biological healing processes to restore homeostasis. While general similarities exist, there are marked differences in the genomics and kinetics of wound healing between the oral cavity and cutaneous epithelium. The lack of successful therapy for oral mucosal wounds has influenced clinicians to explore alternative treatments and potential autotherapies to enhance intraoral healing. The present in-depth review discusses current gold standards for oral mucosal wound healing and compares endogenous factors that dictate the quality of tissue remodeling. We conducted a review of the literature on in vivo oral wound healing models and emerging regenerative therapies published during the past twenty years. Studies were evaluated by injury models, therapy interventions, and outcome measures. The success of therapeutic approaches was assessed, and research outcomes were compared based on current hallmarks of oral wound healing. By leveraging therapeutic advancements, particularly within in cell-based biomaterials and immunoregulation, there is great potential for translational therapy in oral tissue regeneration.

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ObjectiveNeuroscientists have sought to identify the underlying neural systems supporting mental processes involved in social cognition. These processes allow us to interact and communicate with others, form social relationships, and navigate the social world. Through the use of NIMH’s Research Domain Criteria (RDoC) framework, we evaluated consensus among hundreds of studies that examined brain activity during social and social cognition tasks to elucidate, at a large scale, regions comprising the “social brain”. In addition, we examined convergence across tasks corresponding to the four RDoC social constructs, including Affiliation and Attachment, Social Communication, Perception and Understanding of Self, and Perception and Understanding of Others. We assessed activation patterns by performing a series of coordinate-based meta-analyses using the activation likelihood estimate (ALE) method. One meta-analysis was performed on whole-brain coordinates reported from 864 fMRI contrasts of healthy social processing (239 publications; 6,232 participants) using the NiMARE Python package. The meta-analysis of all social contrasts revealed consensus in the “social brain”, including the medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), temporoparietal junction (TPJ), bilateral insula, amygdala, fusiform gyrus, precuneus, and thalamus. Additionally, four separate RDoC-based meta-analyses revealed differential convergence associated with the four social constructs. These outcomes highlight the neural support underlying these social constructs and inform future research on alterations among neurotypical and atypical populations.