Neural systems underlying RDoC social constructs: An activation likelihood estimation meta-analysis

Lobo, Rosario Pintos; Bottenhorn, Katherine L.; Riedel, Michael C.; Toma, Afra I.; Hare, Megan; Smith, Donisha D.; Moor, Alexandra C; Cowan, Isis; Valdes, Javier; Bartley, Jessica E.; Salo, Taylor; Boeving, Emily R.; Pankey, Brianna; Musser, Erica D.; Laird, Angela R.

doi:10.1016/j.neubiorev.2022.104971

Cited by 9 publications

(10 citation statements)

References 86 publications

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“…Subcortical structures, including the basal ganglia and limbic system regions, are structurally and functionally inter-connected with other subcortical [ 11 ] and cortical structures [ 12 – 14 ], serving as the hubs not only for motor control [ 15 ], attention [ 16 ], and emotion [ 17 ] but also for learning [ 18 ], memory [ 19 ], and executive functions such as working memory and inhibitory control [ 20 ]. In addition, subcortical neural substrates of RDoC constructs were recently revealed [ 21 ]. The subcortical and cortico-subcortical circuits are associated with signal pathways of neurotransmitters such as monoamines and amino acids [ 22 – 24 ], and the circuit stemming from subcortical regions can dynamically influence and in turn be influenced by other brain circuits [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification

et al. 2023

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Differential diagnosis is sometimes difficult in practical psychiatric settings, in terms of using the current diagnostic system based on presenting symptoms and signs. The creation of a novel diagnostic system using objective biomarkers is expected to take place. Neuroimaging studies and others reported that subcortical brain structures are the hubs for various psycho-behavioral functions, while there are so far no neuroimaging data-driven clinical criteria overcoming limitations of the current diagnostic system, which would reflect cognitive/social functioning. Prior to the main analysis, we conducted a large-scale multisite study of subcortical volumetric and lateralization alterations in schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder using T1-weighted images of 5604 subjects (3078 controls and 2526 patients). We demonstrated larger lateral ventricles volume in schizophrenia, bipolar disorder, and major depressive disorder, smaller hippocampus volume in schizophrenia and bipolar disorder, and schizophrenia-specific smaller amygdala, thalamus, and accumbens volumes and larger caudate, putamen, and pallidum volumes. In addition, we observed a leftward alteration of lateralization for pallidum volume specifically in schizophrenia. Moreover, as our main objective, we clustered the 5,604 subjects based on subcortical volumes, and explored whether data-driven clustering results can explain cognitive/social functioning in the subcohorts. We showed a four-biotype classification, namely extremely (Brain Biotype [BB] 1) and moderately smaller limbic regions (BB2), larger basal ganglia (BB3), and normal volumes (BB4), being associated with cognitive/social functioning. Specifically, BB1 and BB2–3 were associated with severe and mild cognitive/social impairment, respectively, while BB4 was characterized by normal cognitive/social functioning. Our results may lead to the future creation of novel biological data-driven psychiatric diagnostic criteria, which may be expected to be useful for prediction or therapeutic selection.

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Section: Introductionmentioning

confidence: 99%

Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification

et al. 2023

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“…A compelling argument could be made for the designation of social attention as sub‐construct under the construct of Perception and Understanding of Others (e.g., Itier & Batty, 2009; Mundy, 2018; Stephenson et al, 2021; Tomasello et al, 2005). However, a recent research review suggests that the social process sub‐constructs of Perception and Understanding of Other, Perception and Understanding of Self, Social Communication and Affiliation may reflect a set of social‐cognitive functions that involve activation of a common set of neural circuits (Lobo et al, 2023). Hence, it may not be surprising that certain aspects social attention, such as joint attention, could be considered as a subconstruct under social communication (Charman, 2003; Farrant et al, 2011; Kasari et al, 2008).…”

Section: Social Attention and A Revised Rdoc Frameworkmentioning

confidence: 99%

Research on social attention in autism and the challenges of the research domain criteria (RDoC) framework

Mundy

2023

Autism Research

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The fuzzy nature of categories of psychopathology, such as autism, leads to significant research challenges. Alternatively, focusing research on the study of a common set of important and well‐defined psychological constructs across psychiatric conditions may make the fundamental etiological processes of psychopathology easier to discern and treat (Cuthbert, 2022). The development of the research domain criteria (RDoC) framework is designed to guide this new research approach (Insel et al., 2010). However, progress in research may be expected to continually refine and reorganize the understanding of the specifics of these mental processes (Cuthbert & Insel, 2013). Moreover, knowledge gleaned from the study of both normative and atypical development can be mutually informative in the evolution of our understanding of these fundamental processes. A case in point is the study of social attention. This Autism 101 commentary provides an educational summary of research over the last few decades indicates that social attention is major construct in the study of human social‐cognitive development, autism and other forms of psychopathology. The commentary also describes how this research can inform the Social Process dimension of the RDoC framework.

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“…This significant neurodevelopmental period (23,24) is marked by changes in self-referential cognition (25) that are accompanied by maturational shifts in brain structure and function that occur as a consequence of experiences within one’s social environment (26,27). Such shifts occur in the ventromedial prefrontal cortex (vmPFC), insula, and temporoparietal junction (TPJ) (28), which have been linked to self- and affiliation-based social processes (29). In addition to developing a general sense of self and identity, which is a normative developmental task for all adolescents, Hispanic/Latinx youth are also tasked with establishing an acculturative orientation.…”

Section: Introductionmentioning

confidence: 99%

“…We further expected that biculturalism would be associated with fewer mental health problems among caregivers and their children. We leveraged prior meta-analytic results to guide analyses of brain regions associated with self- and affiliation-based social processing, including the vmPFC, insula, and TPJ (29). Finally, we discuss additional research needed to more fully understand neurobiological mechanisms linked with acculturative experiences.…”

Section: Introductionmentioning

confidence: 99%

Acculturative orientations among Hispanic/Latinx caregivers in the ABCD Study: Associations with caregiver and youth mental health and youth brain function

Meca

Peraza

Riedel

et al. 2022

Preprint

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Background: Population-based neuroscience offers opportunities to examine important but understudied sociocultural factors, such as acculturation. Acculturation refers to the extent to which an individual retains their cultural heritage and/or adopts the receiving society's culture and is particularly salient among Hispanic/Latinx immigrants. Acculturation has been linked to vulnerability to substance use, depression, and suicide and is known to influence family dynamics between caregivers and their children. Methods: We investigated first- and second-generation Hispanic/Latinx caregivers in the ABCD Study and examined how caregivers' acculturative orientation impacts their mental health, as well as the mental health and brain function of their children. Neuroimaging analyses focused on regions associated with self- and affiliation-based social processing (ventromedial prefrontal cortex, insula, and temporoparietal junction). Results: We identified two profiles of caregiver acculturation: bicultural (retains heritage culture while adopting US culture) and detached (discards heritage culture and rejects US culture). Bicultural caregivers exhibited fewer internalizing and externalizing problems compared to detached caregivers; further, youth exhibited similar internalizing effects across caregiver profiles. In addition, youth with bicultural caregivers displayed increased resting-state brain activity (i.e., fALFF and ReHo) in the left insula, which has been linked to psychopathology; however, differences in long-range functional connectivity were not significant. Conclusions: Caregiver acculturation is an important familial factor linked to significant differences in youth mental health and insula activity. Future work should examine sociocultural and neurodevelopmental changes across adolescence to assess long-term outcomes and determine whether localized, corticolimbic brain effects are ultimately translated into long-range connectivity differences.

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Neural systems underlying RDoC social constructs: An activation likelihood estimation meta-analysis

Cited by 9 publications

References 86 publications

Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification

Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification

Research on social attention in autism and the challenges of the research domain criteria (RDoC) framework

Acculturative orientations among Hispanic/Latinx caregivers in the ABCD Study: Associations with caregiver and youth mental health and youth brain function

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