Background: Type 2 diabetes mellitus (T2DM) considered as one of the cardiovascular disorders (CVD) principle risk fac- tor as diabetes is associated with abnormal levels of endothelial function, inflammatory and adipocytokines. Objective: The aim of this study was to measure the impact of weight reducing on inflammatory cytokines, adipocytokines and endothelial function biomarkers among obese T2DM patients. Methods: One–hundred T2DM patients enrolled in the present study; the age range was 35-55 year. Participants shared in this study were enrolled in group (A) received diet control and aerobic exercise on treadmill, while, group (B) had no inter- vention for 3 months. Results: The mean values of body mass index (BMI), tumor necrosis factor –alpha (TNF-α), interleukin-6 (IL-6), leptin, inter-cellular adhesion molecule (ICAM-1) ,vascular cell adhesion molecule (VCAM-1), E-selectin and plasminogen activator inhibitor-1 activity (PAI-1 activity) were significantly decreased and adiponectin was increased significantly in the training group, however the results of the control group were not significant. Also, there were significant differences between both groups at the end of the study. Conclusion: Weight reducing program modulates inflammatory cytokines, adipocytokines and endothelial function bio- markers among obese T2DM patients. Keywords: Diabetes; endothelial dysfunction biomarkers; cytokines; adipocytokines; weight reduction.

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People in wheelchairs spend a long time in the sitting position and often incur alignment problems resulting in neck and back pain. This study: (1) assessed the validity/reliability of Coach's Eye (CE) smart device application, (2) examined the effect of seat to back support angle adjustments on head, neck, and shoulder posture in the sitting position, and (3) compared changes in cervical rotation at each back support angle. Abled subjects sat in a wheelchair with back support angles positioned at 90°, 100°, and 110°. CE, as well as ImageJ software, was used to analyze three angles: sagittal head angle (SHA), cervical angle (CVA), and shoulder angle (SA). There were highly significant differences for CVA and SA (p < 0.001) among the three seat to back support angles. Validity of CE was examined by correlating CE with ImageJ scores. CE had high validity for all angles (r = 0.99, 0.98, 0.99 respectively, p < 0.001). Inter-rater reliability for SHA, CVA, and SA was high (intraclass correlation coefficient [ICC] ranged from 0.95 to 0.99). Head (CVA) and shoulder (SA) alignment was closest to neutral posture with back support angles set at 110° and 90°, respectively.

Background: Activation of immunological and systemic inflammation markers are common in obesity and asthma. Objective: The target of this study was to assess impact of weight reduction on immunological and systemic inflammation markers in obese asthma patients. Material and methods: Eighty asthmatic patients of both sex; their age and body mass index (BMI) mean were 38.72 ± 7.14 year and 32.65 ± 3.18 Kg/m2 respectively. Exclusion criteria included smokers, infections, vaccinations, cancer, surgery, immune system disorders and medications that may influence immune system function as anti-inflammatory medications, analgesics and anti-depressant. All subjects were randomly enrolled in weight reduction group (group A) or control group (group B). Results: The main findings in the present study indicated that weight reducing program in group (A) was associated with significant reduction in the mean values of IL6, TNF-α, and IL8 in addition to significant increase in the mean values of CD4 and CD8 cell count . However, findings of group (B) showed no significant changes. Moreover, Comparison between both groups at the end of the study revealed significant differences. Conclusion: Weight reduction improved immunological and systemic inflammation markers in obese asthma patients. Keywords: Bronchial asthma; cytokines; obesity; immune system; weight reduction.

Introduction.Motor function after stroke may be facilitated by the application of a task-oriented approach which provides both functional and neurological recovery. Also, virtual reality training promotes the restoration of movements by immersing the patient in an entertaining trial of performance. The study aim was to compare the effect of a virtual reality training program and a task-oriented training program on the paretic upper limb function after stroke. Methods. overall, 20 subacute stroke survivors participated in the study. They were randomly allocated to 2 equal groups: an experimental group (A) and a control group (B). Group A performed a virtual reality program and a task-oriented program, while group B performed a task-oriented program only. Assessment was carried out for all participants by using the Upper Extremity Functional index and grip strength test before and after 6 weeks of intervention. Results. Paired t-test revealed that the virtual reality training group (A) presented statistically significant increases in the postintervention mean values of both the Upper Extremity Functional index and hand grip strength compared with the pre-intervention scores (p < 0.05). Furthermore, independent t-test showed a statistically significant difference in the post-intervention mean values between group A and group B. Conclusions. Virtual reality training has a vital role in improving upper limb function and augmenting hand grip strength after stroke. it can be considered more effective than task-oriented training in such cases.

Background and Objectives: Physical activity is essential for adolescents to maintain a healthy lifestyle. The aim of this study was to assess the influence of an 8-week exercise program and motivation on physical activity levels, self-motivation, and mental well-being of adolescents in Saudi Arabia. Moreover, the impact of virtual coaching on physical, emotional, and mental health after an eight-week exercise program was examined. Materials and Methods: Twenty-seven participants, 18 females (67%) and 9 males (33%), with a mean age of 14 ± 2.38 years, were enrolled in eight weeks of pre- and post-intervention between June and August of 2021. The physical activity scale, situational motivation scale, mental health continuum short form, and baseline assessments were completed before and after the eight-week program. The program recommended that adolescents practice aerobic, resistance, and weight-bearing exercises for 60 min daily. Paired mean t-tests were used to compare pre-and post-test results. Results: Participants showed an acceptable physical activity level (5.5 ± 1.4) on a 10-point scale with a significant improvement after the eight-week program (7 ± 1.5; p = 0.013). The situational motivation scale improved from 38.1 ± 16 to 26 ± 19.6 (p = 0.042). The mental health continuum (social and psychological well-being) also significantly improved. Participants who received weekly phone calls showed similar improvement patterns but were not significantly different from those who did not receive calls. Conclusions: A virtually delivered 8-week exercise program for adolescents improved their physical, motivational, and mental health. Providing additional weekly phone calls does not provide additional improvement. Providing adolescents with the needed supervision and motivation enhances their physical activity and mental health.

Background: Restless Leg Syndrome (RLS) is one of the most common causes of sleep disorders that cause functional disability in the lower limb. Due to it is self-limiting, it forces the person to seek treatment. Unfortunately, most of the times, it is misdiagnosed by the doctors and even if it is diagnosed, till date there is no guide program or treatment in the physical therapy. There is huge dearth of knowledge regarding benefits of physical therapy in RLS. Objective: The aim of the present study was to investigate the effect of stretching, strengthening exercises as well as walking on RLS symptoms. Also, to find out the impact of muscle strength and flexibility in relation to the severity of RLS symptoms. Methods: An inquiry of 418 questionnaires randomly distributed was done. A total of 20 participants diagnosed with Restless Leg Syndrome were included in the current study. Pre-post assessment was done for range of motion (by goniometer), functional testing of the foot and ankle, RLS rating scale and RLS ordinal scale. Six participants received physical therapy program for a total of 4 weeks. Twenty patients who had one visit to have the measurement were studied for the correlation study. Results: There was a significant correlation between leg muscles flexibility, strength and the severity of the symptoms. Also, there was a highly significant alleviation of symptoms in the other 6 patients. Conclusion: It can be concluded that physical therapy is effective in relieving symptoms of RLS.

<b>Aim:</b> In the general population, where 6 to 20% of individuals experience anxiety disorders, children also experience a higher burden of anxiety. We undertook a systematic review In order to examine and summarize the results from studies that estimated the prevalence of anxiety and/or its associated risk factors in the pediatric populations of Arab nations, primarily the gulf countries.<br /> <b>Methods:</b> Any study that focused on the pediatric population and completed in Arab nations to determine the incidence of anxiety and/or its risk factors among children under the age of 18. The review had 13 articles were included.<br /> <b>Results:</b> The results of the systematic review found that there was a wide variation in the prevalence of anxiety among children. At least 30.2% of the children were found to suffer from anxiety and the prevalence could go up to 60% in some countries with a higher prevalence among girls than boys. Associated factors of anxiety were diverse including exposure to environmental tobacco smoke, parenting style, living with parents suffering from mental disorders, school type, and being female.<br /> <b>Conclusion:</b> The findings of the review demonstrate the higher prevalence of anxiety among children as almost at least one-third of children suffer from anxiety in the Gulf countries. The program managers and the respective government of these Arab countries need to devise some strategies and interventions that not only focus on the children but also their environment.