To clarify the difference between the interim EQ-5D-5L score and EQ-5D-5L Japanese scoring, and to evaluate the validity of them. MethOds: Five hundred and twenty six patients who received rehabilitation program in six hospitals were asked to administer the EQ-5D-5L. Their occupational therapists were simultaneously administered the EQ-5D-5L as proxy respondents to assess their health-related quality of life (HRQL). The score of the EQ-5D-5L were calculated by the interim value set and new Japanese scoring algorism. The new algorism used TTO model was developed by Japanese EQ-5D team as the national tariff. Pearson's correlations were used to evaluate the concurrent validity of the EQ-5D-5L. Results: Mean age of the patients was 67.1 years. Three hundred and twenty one were male (60.1%). The mean scores of the interim EQ-5D-5L score and Japanese scoring were 0.515 (95%CI; 0.493-0.538) and 0.547 (95%CI; 0.526-0.567), respectively. Significantly results in two tariffs were observed by the modified Rankin scale (mRS) in: mRS1 (0.805 vs 0.850), mRS2 (0.682 vs 0.729), mRS3 (0.604 vs 0.618), mRS4 (0.400 vs 0.410), mRS5 (0.081 vs 0.201). In particular, the strong difference was observed in 5 level of the modified Rankin scale (0.081 vs 0.201). The correlation between the interim score and new Japanese scoring was 0.946. cOnclusiOns: The new Japanese tariff for EQ-5D-5L indicated high validity, but had a few differences with the interim value. We have to mind the differences when use it.
(SR) was conducted using MEDLINE and EMBASE (1996-2017). Key terms included a combination of neurogenic bladder, treatment patterns and epidemiological study. The inclusion criteria for studies were: 1) published in English; 2) conducted in human subjects; 4) reporting the treatment patterns/use in NGB (any neurogenic condition listed in the EAU guidelines); 5) conducted in a real world setting. Articles were reviewed for inclusion by an independent reviewer (AJ) and 10% were cross examined by a second independent reviewer (FF). A narrative synthesis of results was conducted and percentage of treatment use was reported in ranges. Results: A total of eight studies met the inclusion criteria. Study designs, setting, and patient groups were notably heterogeneous and all data was collected before 2008. This SR found that the most commonly used management method amongst NGB patients was reflex voiding (RV) methods and catheterisation (CIC and IndUC). Data and commentary from three studies show that a notable amount of patients switched treatments. The most popular oral pharmacotherapies were alpha-blockers and antimuscarinics used for neurogenic detrusor overactivity (NDO) and detrusor sphincter dyssynergia (DSD). One study which focused on spina bifida reported that the majority of patients underwent surgery. ConClusions: With passing time, clinicians have moved away from techniques associated with higher rates of complications and mortality. This has meant that in recent years, the survival chances of patients with NGB have increased. This suggests that current treatment patterns will be different from what was uncovered in this review. Epidemiological studies using electronic healthcare records (EHRs) are necessary to advance our understanding in how NGB patients are managed in current practice, and how well patterns relate to practice guidelines.
SoC and SoC alone gained 0.3155 QALYs and 0.2752 QALYs, respectively. Hence, ranolazine plus SoC resulted in an ICER of € 4,620 per QALY gained, well below the threshold of € 34,000 per QALY gained, that is twice the annual per capita income. The PSA showed that the likelihood of ranolazine plus SoC being cost-effective at the threshold of € 34,000 per QALY gained was 100%. ConClusions: The results suggest that ranolazine as add-on treatment may be a cost-effective alternative for the symptomatic treatment of patients with chronic stable angina in Greece.
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