Quality Of Life And Emotional Impact Of A Fixed Dose Combination Of Antihypertensive Drugs In Patients With Uncontrolled Hypertension

Abstract

To clarify the difference between the interim EQ-5D-5L score and EQ-5D-5L Japanese scoring, and to evaluate the validity of them. MethOds: Five hundred and twenty six patients who received rehabilitation program in six hospitals were asked to administer the EQ-5D-5L. Their occupational therapists were simultaneously administered the EQ-5D-5L as proxy respondents to assess their health-related quality of life (HRQL). The score of the EQ-5D-5L were calculated by the interim value set and new Japanese scoring algorism. The new algorism used TTO model was developed by Japanese EQ-5D team as the national tariff. Pearson's correlations were used to evaluate the concurrent validity of the EQ-5D-5L. Results: Mean age of the patients was 67.1 years. Three hundred and twenty one were male (60.1%). The mean scores of the interim EQ-5D-5L score and Japanese scoring were 0.515 (95%CI; 0.493-0.538) and 0.547 (95%CI; 0.526-0.567), respectively. Significantly results in two tariffs were observed by the modified Rankin scale (mRS) in: mRS1 (0.805 vs 0.850), mRS2 (0.682 vs 0.729), mRS3 (0.604 vs 0.618), mRS4 (0.400 vs 0.410), mRS5 (0.081 vs 0.201). In particular, the strong difference was observed in 5 level of the modified Rankin scale (0.081 vs 0.201). The correlation between the interim score and new Japanese scoring was 0.946. cOnclusiOns: The new Japanese tariff for EQ-5D-5L indicated high validity, but had a few differences with the interim value. We have to mind the differences when use it.

Symptom experiences in hypertension: a mixed methods systematic review

“…The neurological symptom of headache was the most commonly reported across all quantitative studies [29,30,34,39,42,56,57,63]. Dizziness was the second most commonly reported symptom [29,39,42,56,57,63].…”

“…Conflicts were resolved by a third reviewer (S.M.). After full-text review, 41 articles [29–69] remained for synthesis (see Fig. 1 for PRISMA and Table 1 for included studies).…”

“…Studies were heterogenous and symptoms varied. Symptoms that were common in the literature included headache and dizziness [29,30,34,39,41,42,54,56,57,63], as well as less common symptoms such as restless leg syndrome [60,65]. Some studies were focused on specific symptoms associated with HTN [30,35,36,38,39,[42][43][44][45]50,51,53,55,56,60,65,66,68] while others were aimed at specific population outcomes [29,33,34,41,47,48,52,[61][62][63].…”

“…Most of these studies associated knowledge or lifestyle behavior with beliefs surrounding HTN. Several studies attributed participants reporting 'no symptoms' as a lack of knowledge [34,54,57]. However, cultural factors were influential in three of the studies [34,53,63].…”

Improved quality of life and nonspecific symptoms with fixed‐dose combination drugs

“…In the article “Quality of life and emotional impact of a fixed‐dose combination of antihypertensive drugs in patients with uncontrolled hypertension,” Schmieder and colleagues show how control of hypertension with a fixed‐dose combination (FDC) pill of olmesartan, amlodipine, and hydrochlorothiazide is associated with reduction in patient emotional distress and nonspecific symptoms . These associations support the use of triple‐drug combination therapy over single‐drug therapy and suggest physicians should inquire about nonspecific symptoms when counseling hypertensive patients.…”