R&D issues for the application of Pd-and Ni-catalyzed C À C and C À N coupling reactions in the fine chemicals industry are discussed. In a first part, some background is given on industrial R&D and the role of C À C and C À N coupling for preparative applications is described. The following principal approaches to industrial research are illustrated with relevant examples from the literature and from our own laboratories: i) development of catalysts and catalytic methodologies with industrial potential; ii) finding shorter routes to target molecules using catalytic methods; iii) development of industrial catalytic processes in multi-step syntheses.
Wichtige Pd‐katalysierte Reaktionen von Arylchloriden verlaufen mit entweder isolierten oder in situ erzeugten Palladiumphosphankomplexen (Beispiel siehe Bild) mit hohen Ausbeuten. Die isolierten Katalysatoren sind an der Luft stabil, und die in situ hergestellten können durch Modifizieren der beiden Ausgangskomponenten optimiert werden.
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