Our prior (EB08 Abs.738.4) cross sectional study suggested that bilateral chronic aortic baroreceptor denervation (AD) induces salt‐sensitive normotension in rats. To assess this in depth, mean arterial pressure (MAP) was measured intra‐arterially over time (3 times) in two groups of conscious Wistar rats. The first time (PreDen) was measured in caudal artery before random sham (SH, n = 7) or real AD (n = 10); the second one was measured in left femoral artery after 7 days on low sodium diet (PostDen LNaD = 0.04% Na) and the third time was measured in right femoral artery after 21 days on high sodium diet (PostDen HNaD = 8% Na). The effectiveness of AD was judged by Box‐Cox transformation of PHE(1) and SNP (2) slope [((( [3 ‐ (HR2‐HR1/ MAP2‐MAP1)] −0.4) ‐1) / ‐0.046)] obtained in conscious state. Salt Sensitivity = SS = (PostDen HNaD MAP ‐ PostDen LNaD MAP, mmHg). Delta of MAP (PostDen MAP ‐ PreDen MAP, mmHg) on both LNaD and HNaD were calculated too. &p = 0.05, *p <0.003 vs SH and + p < 0.01, # p < 0.009 vs LNaD.PreDen PostDen PostDen SS Delta MAP DeltaMAPLNaD HNaD LNaD HNaDSH 105.0 114.0 122.0+ 7.7 9.0 16.7+±2.7 ±1.8 ±1.7 ±2.5 ±2.6 ±2.3AD 101.0 123.2& 134.5*# 11.3 22.2* 33.5*#±2.0 ±2.4 ±2.8 ±2.6 ±2.0 ±2.4ConclusionsWistar rats show salt‐sensitive normotension that chronic AD switches to salt‐sensitive hypertension. Supported by: CONACYT 62282
To assess whether progressive arterial baroreceptor denervation results in salt‐sensitive changes in blood pressure, mean arterial pressure (MAP) was measured in six groups of conscious male Wistar rats before and ∼30 days after bilateral: a) sham denervation (SH), b) sino‐aortic denervation (SD) and c) aortic denervation (AD). During the last 21 days of post‐denervation period three groups received high sodium diet (HNa = 8%) and the other three groups low sodium diet (LNa = 0.04%). The remaining baroreflex control of ERSNA was examined in the anesthetized state as %Δ ERSNA vs MAP. The modelling indicated that there were no effects of denervation nor diet on MAP ∼ 30 days after denervation. However, the modelling of Δ MAP (MAP after – MAP before) indicated effect of both denervation and diet but not interaction, the highest and more lasting Δ MAP being observed in AD + HNa group (21± 3 mmHg). The modelling of remaining baroreflex control of ERSNA indicated effect of denervation but not of diet.Conclusion:AD + HNa is a novel experimental model of salt‐sensitive normotension, though AD does not impair the remaining baroreflex control of ERSNA.Supported by: SMRF06‐UASLP Range % Slope %/mmHg X to ½ range mmHg Lower Plateau % Gmax SH 119± 7 −.085±.007 130±5 −85±6 −2.5±0.1 AD 125± 9 −.065±.005* 128±4 −82±5 −2.0±0.2 SD 61± 6* −.059±.005* 153±7* −66±6* −.9±.1* p<0.05 vs SH. Conclusion:AD + HNa is a novel experimental model of salt‐sensitive normotension, though AD does not impair the remaining baroreflex control of ERSNA.Supported by: SMRF06‐UASLP
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