Purpose:To evaluate that Connexin (Cx43) plays a role in lesions after hepatic
ischemia/reperfusion (IR) injury.Methods:We use Cx43 deficient model (heterozygotes mice) and compared to a wild
group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The
heterozygote genotype was confirmed by PCR. We analyzed the hepatic enzymes
(AST, ALT, GGT) and histology.Results:The mice with Cx43 deficiency showed an ALT mean value of 4166 vs. 307 in the control group (p<0.001); AST mean value of 7231 vs. 471 in the control group (p<0.001); GGT mean value of 9.4 vs.
1.7 in the control group (p=0.001); histology showed necrosis and
inflammation in the knockout group.Conclusions:This research demonstrated that the deficiency of Cx43 worses the prognosis
for liver injury. The topic is a promising target for therapeutics
advancements in liver diseases and procedures.
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