Living organisms take nutrients from the environment, and together with them, substances with toxic potential � such as heavy metals. Lead is one common metal pollutant especially in aquatic environment, from where the fish can be intoxicated very easily. Bioavailability, distribution, toxic action, synergistic and antagonistic effects are characteristics which can alter the fish health. Our experimental study followed the effects of lead overload in water on iron distribution, in different tissues sample Carassius gibelio Bloch fish. We performed the experiment in four different fish groups: control C; lead � Pb (administration of lead in water 0.075mg/mL of water, as Pb(NO3)2 x � H2O); lead (the same dose) and 2% of freeze-dry garlic incorporated into fishes� food � Pb+garlic; lead (the same dose) and 2% chlorella incorporated into fishes� food � Pb+chlorella, for 21 consecutive days. The iron concentration was analysed with AAS (Atomic Absorption Spectroscopy) from gills, muscle, skin (and scales), intestine, liver, heart, brain, ovary, testicles, and kidney. The obtained data presented a significantly decrease of iron content in all tested tissue samples that demonstrated, alteration of iron homeostasis, explained by a strong antagonistic effect of lead on iron. Our experiment showed that biologic active principles from garlic and chlorella act like natural protectors, and potentiate the iron deficiency even in the case of lead overload in aquatic environment, for fish.
Environmental pollution negatively affects the aquatic ecosystems. Heavy metals are considered dangerous toxic elements for aquatic biota, as metallic elements or as salts which exhibit great stability. Among these, lead is toxic for all aquatic biotic components. Our research investigated the manganese distribution in tissue of Prussian carp fishes after lead intoxication, highlighted also the lead detoxifying potential of active principles from garlic and chlorella (powder). For our experiment 120 Prussian carp fingerlings, weighing 22-25g each, for 21 consecutive days, were divided according to the following treatments: C group (without treatment), E1 group (75ppm Pb in water as Pb(NO3)2 x �H2O), E2 group (75ppm Pb in water+2% freeze-dry garlic in feed), E3 group (75ppm Pb in water+2% freeze-dry chlorella in feed). At the end of the experimental period, tissue samples (gills, muscle myotomers�epaxial, heart, skin and scales, intestine, liver, brain, gonads, kidney) were collected after euthanasia with clove oil. Manganese concentration was analytical performed using AAS (atomic absorption spectrometry). Using fish as bioindicators of lead experimental contamination allowed us to obtain valuable informations about its ability to substitut/remove bioactiv minerals from animal tisssues. In the same time, we could emphasize the efficiency of natural antioxidants or chelators of edible plants (such as garlic) or algae (such as chlorella), to alleviat the lead impact on homeostasis of trace elements from tissues.
In living organisms lead is classified as potential toxic metal, and in high concentration can produce intoxication with the alteration of some vital organs, especially liver and kidney. In aquatic environment lead can be absorbed by fishes and other organisms, with different distribution in various tissues. Our aim of experiment was to verify and demonstrate the protective effect of lyophilized garlic and chlorella against bioaccumulation of lead in fishes living in aquatic environment deliberated polluted with lead. Thus, lyophilized garlic and chlorella administrated as supplements in fodder for fishes (Carassius gibelio) diminished the antagonistic effect of lead against zinc in all tested tissues: liver, kidney, heart, brain, ovary, testis, muscles myotome -epaxial, skin -with scales, gills, and intestine.
Rationale:The prevalence of obesity has increased over the past few years, becoming a public health problem. Generally, the primary therapeutic remedies are diet, physical exercise, medication, and bariatric surgery. However, an increased number of obese and overweight people are using complementary and herbal slimming supplements.Patient concerns:A 70-years-old Caucasian woman presented to the outpatient clinic with tachycardia (>100 bpm), insomnia, anxiety, and recent weight loss (6 kilos in 3 months). She had no previous thyroid disease, but she presented transient hyperthyroidism at 3 months after ingestion of tablets containing kelp seaweeds.Diagnoses:Hypertensive and obese patient, without previous thyroid disease, presented with transient hyperthyroidism at 3 months following ingestion of tablets containing kelp seaweed.Interventions:The kelp-containing tablets were discontinued, and antithyroid therapy with Methimazole was initiated as follows: Methimazole at 15 mg/day for 1 month, at 10 mg/day in the second month, and 5 mg/day for the third month.Outcomes:After 3 months of antithyroid therapy and without the consumption of kelp - containing tablets, normal thyroid function was regained. Further analysis revealed normal thyroid function, so the hyperthyroidism reversed completely.Lessons:Adults who consume complementary medication based on kelp seaweed should be informed of the risk of developing thyroid dysfunction also in the absence of any pre-existing thyroid disease. Due to the high iodine content, supplements containing kelp should be taken with the supervision of a physician and with monitoring of thyroid function.
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