Due to source contamination and wearing of instrument components problems caused by the direct insertion probe technique, a new way of introduction of low volatile compounds into mass spectrometer was tested. This new scheme comprises the introduction of the low volatile compounds solutions via a six port valve connected to a particle beam interface. Solutions of isatin were injected into this system and the best resultswere obtained with CH 2 Cl 2 , CH 3 OH and CH 3 CN. The solution inlet system has shown to be advantageous over the conventional way of direct insertion probe introduction.
Hydroaminomethylation (HAM) is a tandem catalytic process that allows accessing amines from olefin scaffolds and is perfectly aligned with green chemistry precepts. In this work, HAM was applied to the natural hydroxyolefins: isoprenol, linalool, nerolidol, and isopulegol. Employing 4‐methylpiperidine, morpholine, and 1,2,3,4‐tetrahydroisoquinoline as counterparts, several new, structurally complex amines were prepared from biorenewable, low‐cost substrates, opening a path to exploit this structure diversity in biological activity. By the appropriate choice of rhodium‐based catalytic systems, as well as the reaction conditions, the necessary fine tuning for each counterpart was achieved. The unpromoted rhodium system leaded mostly to aminoalcohols, while certain phosphorus(III)‐promoted rhodium systems afforded amines containing a tetrahydropyran or a tetrahydrofuran moiety in moderate to high yields.
Convenient One-Pot Synthesis of 4,8-Dimethyl-bicyclo(3.3.1)non-7en-2-ol via Platinum/Tin Catalyzed Hydroformylation/Cyclization of Limonene.-Under optimized conditions limonene (I) is transformed in a one-step process to the alcohol (III), which is a useful compound in the perfumery industry. Together with the desired compound 11% of hydrogenated and 4% of isomerized material is found. In the absence of Sn-or Pt-complexes no hydroformylation is observed. -(DE O. DIAS, A.; AUGUSTI, R.; DOS SANTOS, E. N.; GUSEVSKAYA, E. V.; Tetrahedron Lett. 38 (1997) 1, 41-44;
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