Fluoxetine and escitalopram are FDA-approved prescription medications for pediatric depression, but not the only agents used. We examine adolescent overdose risks of bupropion and SSRIs. What's Known on This Subject Adolescents who attempt self-harm by overdose often choose medications of convenience, and frequently have access to antidepressants. SSRIs are the drugs of choice in pediatric depression; however, bupropion is also prescribed. A recent study highlighted bupropion's toxicity in adolescents. 8
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Healthcare providers should be aware of the potential for this phenomenon to occur in poisoned patients. It should be documented as physical evidence of overdose in addition to clinical evidence.
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