Nanoparticles of zeolitic imidazolate framework-7 (nZIF-7) were blended with poly(ether imide) (PEI) to fabricate a new mixed-matrix membrane (nZIF-7/PEI). nZIF-7 was chosen in order to demonstrate the power of postsynthetic modification (PSM) by linker exchange of benzimidazolate to benzotriazolate for tuning the permeability and selectivity properties of a resulting membrane (PSM-nZIF-7/PEI). These two new membranes were subjected to constant volume, variable pressure gas permeation measurements (H, N, O, CH, CO, CH, and CH), in which unique gas separation behavior was observed when compared to the pure PEI membrane. Specifically, the nZIF-7/PEI membrane exhibited the highest selectivities for CO/CH, CO/CH, and CO/CH gas pairs. Furthermore, PSM-nZIF-7/PEI membrane displayed the highest permeabilities, which resulted in H/CH, N/CH, and H/CO permselectivities that are remarkably well-positioned on the Robeson upper bound curves, thus, indicating its potential applicability for use in practical gas purifications.

We synthesized eight new bipyridine and bipyrimidine gold (III) dithiocarbamate-containing complexes (C1–C8) and tested them in a panel of human cancer cell lines. We used osteosarcoma (MG-63), lung (A549), prostate (PC3 and DU145), breast (MCF-7), ovarian (A2780 and A2780cis, cisplatin- and doxorubicin-resistant), and cervical (ME-180 and R-ME-180, cisplatin resistant) cancer cell lines. We found that C2, C3, C6, and C7 were more cytotoxic than cisplatin in all cell lines tested and overcame cisplatin and doxorubicin resistance in A2780cis and R-ME-180 cells. In the PC3 prostate cancer cell line, the gold (III) complex C6 ([Au2(BPM)(DMDTC)2]Cl4) induced apoptosis and double-stranded DNA breaks, modified cell cycle phases, increased Reactive Oxigen Species (ROS) generation, and reduced thioredoxin reductase and proteasome activities. It inhibited PC3 cell migration and was more cytotoxic against PC3 cells than normal human adipose-derived stromal cells. In mice bearing PC3 tumor xenografts, C6 reduced tumor growth by more than 70% without causing weight loss. Altogether, our results demonstrate the anticancer activity of these new gold (III) complexes and support the potential of C6 as a new agent for prostate cancer treatment.

Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. KAUST Repository M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPTTwo new linear gold(I) complexes of formulae [Au{P(t-Bu) 3 }(S 2 CN(CH 3 ) 2 )] (2), and [Au{P(tBu) 3 }(S 2 CN(C 2 H 5 ) 2 )] (3) have been prepared. The structure of these complexes have been determined by single X-ray crystallography. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPTCorresponding author Dr. A. A. Isab (aisab@kfupm.edu.sa) 32 M A N U S C R I P T A C C E P T E D 127The C=S thiocarbonyl stretch splits into two peaks (doublet) at 1022, 972 cm -1 and 1020, 989128 cm -1 with medium intensity in the spectra of complexes (2) and ( 142The band at 304 cm -1 in the far-IR spectrum of complex (1) Table 2. A small upfield shift for methyl protons of tri-ter-butyl group was observed 148 for complex (2) compared to complex (1). Whereas, a small downfield shift for methyl protons 149 of tri-ter-butyl group have been observed for complex (3) as shown in X-ray structure of complex (3) is shown in Figure 2. There are two independent molecules of 181 gold(I) complex in the asymmetric unit cell. In both molecules, gold(I) atom is coordinated with 182 one P donor atom of tri-ter-butylphosphine ligand and S atom of diethyl dithiocarbamate ligand. 183There are only minor conformational differences between x-ray structure of two molecules. 184The Au1-S1 and Au2-S3 bond distances are 2.3293 (15) 1.04 µM as given in Table 4. 227The in vitro cytotoxicity in terms of IC 50 values against A549 cell line were found 41.60 ± 3.00, were applied using the SCALE3 ABSPACK [68]. Graphics were generated using PLATON [69]. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 296A summary of crystal data and refinement details for gold(I) complexes (2) and (3) are given in 297 Table 5. Selected bond lengths and bond angles are given in Table 6. Res. 66 (2006) labelling scheme and displacement ellipsoids drawn at 50% probability level. • Gold(I) complexes of the type P-Au(I)-S were synthesized.• Cytotoxicity of complexes measured on A549, HeLa and MCF7 cell lines.• X-ray data shows the gold coordination sphere adopts a linear geometry Control 100.9 ± 2.9 98.7 ± 2.7 99.8 ± 2.43.12 93.6 ± 2.4 50.6 ± 1.5 53.9 ± 1.96.25 89.5 ± 2.3 34.4 ± 0.9 38.6 ± 1.2 12.5 81.9 ± 1.9 19.5 ± 1.4 27.9 ± 1.0 25 27.3 ± 1.5 15.3 ± 1.1 22.9 ± 1.2 50 12.4 ± 1.1 8.7 ± 1.2 9.41 ± 1.16 M A N U S C R I P T A C C E P T E D

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