(1)H and (13)C NMR chemical shifts of alpha- and beta-anomers of adenosine, 2'-deoxyadenosine and their acetate derivatives were completely and definitely assigned using the concerted application of one- and two-dimensional experiments (gCOSY, gNOESY, gHSQC and gHMBC). The influence of the stereochemistry of the purine base on the NMR data of the hydrogen and carbon atoms of the furanose moiety was estimated.
Baker's yeast reduction of 1 -(4-methoxyphenyl)propan-2-one, 4-phenylbutan-2-one, and 2-hydroxy-1 -(4-methoxypheny1)ethanone (p-methoxyphenacyl alcohol), afforded in good yield and high optical purity the corresponding (S) -alcohols and the (R)-diol, but only after careful investigation of incubation conditions. Protection of the above hydroxy compounds, and ruthenium tetraoxide oxidation of their acetates, afforded the corresponding acetoxy acids in good yield and high optical purity. ( S ) -I -
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