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Therefore, chronic nefazodone induces antinociceptive and antidepressant-like effects in rats and increases mu-opioid receptor expression in brain areas related to pain and affective state. These results suggest that antidepressants could be effective on somatic and affective dimensions of pain and this action could be related to its influence on the opioid system.

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SUMMARYChronic fluoxetine administration in rats generates a significant decrease in NPY immunostaining in the paraventricular and supraoptic nuclei, with respect to controls. However, a significant increase was found in arcuate nucleus. A lack of changes was observed in periventricular and suprachiasmatic nuclei, lateral hypothalamic area and medial preoptic area. Similar results were observed after chronic administration of sertraline. NPY expression is altered in appetite regulatory regions after in vivo chronic treatment with selective serotonin reuptake inhibitors, suggesting that arcuate-paraventricular NPY projection impairment is involved in the anorectic effects of these drugs. KEY WORDSFluoxetine, sertraline, NPY, selective serotonin reuptake inhibitors, rat brain INTRODUCTION

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