Selective serotonin reuptake inhibitors alter NPY immunostaining in the rat hypothalamus

I, Acebes; Saracibar, Gonzalo; Echevarrı́a, Enrique; Casado, A.; Valiente, F.J.; Pascual, Jesús; Casis, Luı́s

doi:10.1002/nrc.10030

Cited by 3 publications

(1 citation statement)

References 24 publications

(25 reference statements)

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“…Fluoxetine administration significantly reduces food intake in obese Zucker rats, due, at least in part, to a reduction in hypothalamic NPY arcuate-paraventricular projection axonal transport (22,23), also observed in lean rats (24). Accordingly, in the results here reported, chronic fluoxetine administration increased the numbers of neural cells positively immunostained for mu opioid receptor in the hypothalamic paraventricular nucleus, suggesting the involvement of opiodergic neural circuits at this level in NPY-mediated fluoxetine anorectic action.…”

Section: Discussionsupporting

confidence: 57%

Fluoxetine alters mu opiod receptor expression in obese Zucker rat hypothalamus

Churruca

Casis

Portillo

et al. 2004

Neuroscience Res Communica

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SUMMARYThe aim of the present work was to study the potential involvement of hypothalamic opioid system in the anorectic mechanism of fluoxetine in obese Zucker rats, assessing the effects of chronic fluoxetine treatment on mu opioid receptor immunostaining in several hypothalamic regions. Male obese Zucker (fa/fca) rats were administered with fluoxetine (10 mg/kg; i.p.) daily for two weeks. The control group was given 0.9% NaCl solution. Regional hypothalamic immunostaining for mu opioid receptor was carried out. Fluoxetine administration increased the numbers of neural cells positively immunostained for mu opioid receptor in the hypothalamic paraventricular, arcuate, ventromedial and suprachiasmatic nuclei, as well as the medial preoptic and lateral hypothalamic areas, without changes in dorsomedial, supraoptic and periventricular nuclei, and the lateral preoptic area. These results suggest the involvement of hypothalamic opioid system in fluoxetine-induced anorexia in obese Zucker rats. Increased regional hypothalamic density of neural cells expressing mu opioid receptors after fluoxetine treatment could be a compensatory mechanism against a possible reduction in opioidergic tone.

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Section: Discussionsupporting

confidence: 57%

Fluoxetine alters mu opiod receptor expression in obese Zucker rat hypothalamus

Churruca

Casis

Portillo

et al. 2004

Neuroscience Res Communica

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Effects of fluoxetine administration on hypothalamic melanocortin system in obese Zucker rats

et al. 2008

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Sibutramine Decreases Body Weight Gain and Increases Energy Expenditure in Obese Zucker Rats without Changes in NPY and Orexins

Casado

́guez

Portillo

et al. 2003

Nutritional Neuroscience

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The aim of the present work was to describe the effects of sibutramine on body weight and adiposity and to establish the potential involvement of neuropeptide Y (NPY) and orexins in the anorectic action of this drug. Male obese Zucker rats were daily administered with sibutramine (10 mg/kg, intraperitoneal) for two weeks. Carcass composition was assessed using the official methods of the Association of Official Analytical Chemists. Total body oxygen consumption was measured daily for 60 min before sibutramine or saline injection and for 30 min (from 60 to 90 min) after drug or saline injection. Hypothalamic arcuate and paraventricular nuclei, and the lateral hypothalamic area were immunostained for NPY, orexin A and orexin B. Commercial kits were used for serum determinations. Reductions in body weight and adipose tissue weights were observed after sibutramine treatment in obese Zucker rats. No changes in NPY immunostaining in the arcuate and paraventricular nuclei were found. Orexin A and orexin B immunostaining was not modified in the lateral hypothalamic area in treated rats. The reduction in body weight and adiposity induced by sibutramine was achieved by both a reduction in food intake and an increase in energy expenditure. NPY and orexins do not seem to be involved in the anorectic effect of sibutramine.

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Selective serotonin reuptake inhibitors alter NPY immunostaining in the rat hypothalamus

Cited by 3 publications

References 24 publications

Fluoxetine alters mu opiod receptor expression in obese Zucker rat hypothalamus

Fluoxetine alters mu opiod receptor expression in obese Zucker rat hypothalamus

Effects of fluoxetine administration on hypothalamic melanocortin system in obese Zucker rats

Sibutramine Decreases Body Weight Gain and Increases Energy Expenditure in Obese Zucker Rats without Changes in NPY and Orexins

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