Background: The liver has a vital role in the hemostatic system. It is the site of synthesis of proteins responsible for clotting factors and their inhibitors. Liver infections/ diseases pose the effective functioning of the liver enzymes and clotting profiles. Objective of Study: This retrospective study aims to determine the plasma level of APTT, PT, in patients with chronic disease state in the University of Abuja Teaching Hospital, Gwagwalada, Nigeria. Materials and Methods: A total of 144 participants were enrolled for this study; both PT and APTT were analyzed using Quick and kaolin methods, respectively. Results: 144 candidates who met the inclusion criteria were recruited for this study. table 1.0 and 2.0 showed relationship between PT and APTT in liver infections/ diseases respectively, among the subjects, 81 subjects had Asymptomatic HBV Infection with mean ± SD of 15.3704± 3.0391, 18 Asymptomatic HCV infection, 2 HBV and HCV coinfection, 34 Chronic HBV, 6 Chronic HCV, 1 HCV/HIV coinfection, 1 Chronic HCV /HIV coinfection, 1 HBV/HIV coinfection, and Liver cirrhosis. They was non-statistically significant decrease in the level of PT among patients with both asymptomatic and chronic HBV, HCV, HBV and HCV co-infection, HBV co-infection with HIV, HCV co-infection with HIV and patients with liver cirrhosis with P-value of 0.229. Conclusion: Findings from this study demonstrated that coagulation profile has an association with liver disease.
Background: The pathological events during diabetes mellitus (DM) and hypertension (HTN) could induce hyper-vascular injuries and coagulopathies in affected patients. Thus, this prospective comparative study aims to assess the prothrombin time (PT), partial thromboplastin time with kaolin (PTTK) and international normalized ratio (INR) as biomarkers of potential coagulopathies in diabetics with hypertension (test group) and those without hypertension (control group) at Specialist Hospital Sokoto, North-western Nigeria. Materials and methods: Whole blood samples were obtained from 74 diabetic patients with hypertensive and 37 diabetic patients without hypertension and analysed for the PT, PTTK and INR values using commercially available kits. The sociodemographic variables of the enrolled participants were collated and statistically analysed against the coagulometric values using suitable tests. Results: Participants between 50-59 years (39.2%) were the most frequently enrolled participants, followed by 40-49 years (29.73%). Females comprised 56.8% while males were 43.2% of the participants. The PT, PTTK and INR were not statistically significant between diabetes with hypertension and diabetes without hypertension which were (9.22 ± 1.78, 30.27 ± 18.18 and 0.70 ± 0.15) and (9.51 ± 1.85, 36.57 ± 17.17 and 0.72 ± 0.14) respectively (p = 0.532, p = 0.061 and p= 0.575). The age group of the subjects showed a significant increase in PTTK when compared with PT and INR (p = 0.392, p = 0.002 and p = 0.467). There were increases but statistically non-significant in PTTK when compared with PT and INR based on occupation (p =0.833, p = 0.000 and p = 0.779) respectively. Conclusion: Findings from this study showed no significant variation in PT, PTTK and INR of diabetics and diabetics with hypertension. However, future studies could be done to focus on platelet factors and other highly sensitive biomarkers of the coagulation system of these populations. Nevertheless, monitoring the PTTK in older diabetic patients with diabetes mellitus is important to prevent hypercoagulation.
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