Introduction: Determination of the true prevalence of Helicobacter pylori (H. pylori) is difficult in a hyper-endemic area like Nigeria with use of

Background:The knowledge of medical ethics is essential for health care practitioners worldwide. The main objective of this study was to evaluate the knowledge of medical doctors in a tertiary care hospital in Nigeria in the area of medical ethics.Materials and Methods:A cross-sectional questionnaire-based study involving 250 medical doctors of different levels was carried out. The questionnaire, apart from the bio-data, also sought information on undergraduate and postgraduate training in medical ethics, knowledge about the principles of biomedical ethics and the ethical dilemmas encountered in daily medical practice.Results:One hundred and ninety (190) respondents returned the filled questionnaire representing a response rate of 76%. One hundred and fifty-two respondents (80%) have had some sort of medical ethics education during their undergraduate level in the medical education. The median duration of formal training or exposure to medical ethics education was 3.00 hours (range: 0-15). One hundred and twenty-nine respondents have read at least once the code of medical ethics of the Medical and Dental Council of Nigeria while 127 (66.8%) have some general knowledge of the principles of biomedical ethics. The breakdown of the identified ethical dilemmas shows that discharge against medical advice was the most identified by the respondents (69.3%) followed by religious/cultural issues (56.6%) while confidentiality was recognized by 53.4%.Conclusion:The knowledge of medical ethics by Nigerian medical doctors is grossly inadequate. There is an urgent need for enhancement of the teaching of the discipline at both undergraduate and postgraduate levels in Nigeria.

Background: This study was conducted to determine the prevalence of hepatitis C virus antibody (anti-HCV), among a healthy university undergraduate population in south-western Nigeria. Materials and Methods: Relevant medical information of students who underwent the post-admission screening exercise for the year 2012, at the Ladoke Akintola University of Technology (LAUTECH), Health Center, Ogbomoso were extracted from the laboratory log book. All tests were done using rapid anti-HCV test kit by Health -Chem diagnostics, USA. A total of 1,572 students were included in the study. The mean age was 19.61 (± 2.75) years while the age range was 15-50 years. A total of 821 (52.20%), of the subjects were males while 751 (47.80%) were females. More than ninety nine percent (99.90%) of the subjects were aged 15-30 years, whereas those aged ≥31 years were comparatively few (0.60%). Results: Of the 1572 students, 6 tested positive, giving an overall prevalence of 0.40%. Three (0.37%) of the 821 male subjects tested positive while 3(0.40%) also of the 751 female subjects tested positive. Age-group 21-30 years had the highest prevalence of anti -HCV (0.50%), followed by agegroups ≤ 20 years with 0.30% prevalence. None of the subjects in age-groups 31-40 and ≥ 41 years tested positive. Conclusion: These observed differences were not statistically significant. The prevalence of Hepatitis C Virus is low among the young healthy undergraduate population in the south -western region of Nigeria.

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Introduction: Diarrhoea, in general, is well investigated but the epidemiology of Functional Diarrhoea (FDr) as a disease entity has not been adequately evaluated globally, and more especially, in the sub-Saharan African population. Aim: To determine the prevalence and risk factors of FDr, and the associated quality of life in a Nigerian community. Materials and Methods: The study was a community-based cross-sectional survey involving 515 consenting adults aged 18-70 years. Data collection was done from February to March 2019. Ten participants were excluded because of inappropriately filled questionnaires, thus leaving a total of 505 subjects. The research instrument contained sociodemographic information, the Rome IV Functional Bowel Disorder questionnaire, the Short Form 12, version 2 Health Survey (SF-12v2) questionnaire, the Beck Depression and Anxiety Inventories, the Pittsburgh Sleep Quality Index (PSQI), and the Early Trauma Inventory-Self Report. Respondents who were positive for FDr were the cases while those who had no FDr were the controls in the data analysis. Independent Student t-test was used to compare means. The odds ratios of prospective risk factors of FDr were calculated with logistic regression. Odds Ratios (OR) >1 and p-value ≤0.05 were considered significant. Results: The mean age of the participants was 32.7±12.9 years. Six participants {1.2% (95% CI, 0.4%-2.4%)} had FDr with a 1:2 Male/Female ratio. Functional diarrhoea had a statistically significant association with depression (18.0±12.8 vs 8.2±9.5, p-value=0.021) only among the possible risk factors considered. The mean SF-12v2 scale scores, except Vitality, were lower in subjects with FDr than the controls, though only Social Functioning was statistically significant (p-value=0.003). Conclusion: The prevalence of FDr is low in the present study population. The disease is associated with depression and it impacts the Health-Related Quality of Life (HRQoL) negatively.