Amphotericin B is a polyene antifungal agent with activity in vitro against a wide variety of fungal pathogens. Amphotericin B exerts its antifungal effect by disruption of fungal cell wall synthesis because of its ability to bind to sterols, primarily Ergosterol, which leads to the formation of pores that allow leakage of cellular components. This affinity may also account for its toxic effects against select mammalian cells. Amphotericin B is generally considered cidal against susceptible fungi at clinically relevant concentrations. The gel was formulated by changing the polymer ratio. FT-IR study confirmed the purity of drug and revealed no interaction between the drug and excipients. Gel formulations were characterized for drug content, pH determination, drug content, in-vitro drug release and particle size. Among the nine formulations, F9 was selected as the best formulation as its %CDR after 08 hours was 93.92%. The drug content of the F9 formulation was 98.12%. Gel formulation F9 was found to be stable at 30 ±2°C and 65 ± 5 RH. It was found that at 40 ± 2°C and 75 ± 5 RH the gel formulation was not stable and %CDR was decreased.
The aim of the present study was to investigate the aquasome as potential carriers for efficient oral delivery of Bromelain in order to improve its bioavailability. Aquasomes prepared by inorganic core of calcium phosphate covered with a sugar film and further adsorption of the Bromelain and characterized in terms of the morphological examination, particle size distribution, entrapment efficiency, drug loading and in vitro release. The surface morphology of the freeze-dried aquasomes were smooth, discrete with a regular spherical to near-spherical shape. Size of the aquasomes after freezedrying was 473 mm and well-distributed. The zeta potential of microspheres was -11.1 mV. Entrapment efficiency and drug loading of different aquasome formulation was found to be 72.0±2.13 to 79.6±0.95 and 2.78±0.05 to 3.98±0.06 respectively. The cumulative release rate of bromelain aquasomes was followed by a sustained release. The release following Korsmeyer-Peppas Model and from the 'n' value we see that the release followed the Non-Fickian release mechanism. That means here the release is occurred by diffusion as well polymeric chain erosion.
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