Aquasomes as a Carrier System for Oral Delivery of Bromelain

Kutlehria, Abhilash; Kaushik, Peeyush; Sharma, Shaveta; Kaur, Amandeep

doi:10.7897/2230-8407.098177

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…The interest to develop a carrier for bromelain can be expressed by the high number of the published studies; thus, there have been reported the obtaining of bromelain capped gold nanoparticles [12] and the development of aquasomes for its oral delivery [13]. A bacterial cellulose membrane containing bromelain was presented in the literature [2]; the authors found that their carrier can improve the antimicrobial activity 9 times than the pure substance.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain

Sas¹,

Borcan²,

Sas³

2023

Mater. Plast.

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Bromelain, a natural substance sourced from pineapples, was found effective in various colds, in preventing heart attack and respectively in excess weight. On the other hand, it is well-known that pineapples juice increases the gastric acidity and respectively the people with hemophilia, internal bleeding must also be very careful in consuming this fruit. The objectives of this study were to obtain and to characterize a drug delivery system used for the transmembrane transfer of bromelain. The samples based on polyurethane matrices with and respectively without bromelain were synthesized and characterized by measurements of pH, encapsulation efficacy, cumulative drug release in a degradative media and in simulated gastric acid, electron microscopy and by modern techniques such as Zetasizer, cytotoxicity assay, and various non-invasive skin irritation assessment. The results indicate the obtaining of polyurethane matrices with mean sizes between 322-342 nm and neutral pH, that have a medium stability against the clusters formation tendency and a medium drug release rate. The non-irritative potential and the results on their cytotoxicity are important evidences that can be used for the further clinical trials of the polyurethane carriers.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain

Sas¹,

Borcan²,

Sas³

2023

Mater. Plast.

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“…(50) successfully immobilized DNAase (therapeutic enzyme) on the surface of the aquasomes and was able to target the specific site of action and to bring about a prominent therapeutic effect as desired. Bromelain multi-particulate drug carrier for oral delivery (53) Hepatitis B Vaccine Antigen for prevention of jaundice (36) Haemoglobin carrier for oxygen (26) Merozoite Surface Protein-119 (MSP-119)…”

Section: Fundingmentioning

confidence: 99%

Aquasomal drug delivery system: A special emphasis on the formulation techniques and applications

Rajak,

Islam,

Karmakar

et al. 2023

Ars Pharm

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Introduction: Aquasome is a self-assembled nanoparticulate carrier system with three layers. The system is made up of a polyhydroxy oligomer-coated inner nanocrystalline solid core. Adsorbed on the coated layer are drug molecules or biochemically active compounds. Self-assembly in this sense refers to the independent formation of molecules into organised, long-lasting, and non-covalently bonded patterns.This paper gives an overview of aquasome formation, covering structural properties, formulation methodologies, and the benefits and drawbacks of this novel drug delivery technology. The article primarily addresses the formulation processes used to create self-assembled nanostructures and their various possible applications. Method: Several online databases, including Science Direct, Medline, Web of Science, Google Scholar and Scopus, were used in the literature search. The datasets were searched for entries of studies up to July, 2023. The review paper especially addresses many elements of aquasome formation by various researchers employing methods/modified techniques such as co-precipitation, self-precipitation, sputtering, and and so forth. It also illustrates a variety of fields of therapy in which aquasome has been recognised to have a major influence, such as oxygen and extract carrier. Results: The solid core is responsible for providing structural stability, while the oligomeric coating is crucial for safeguarding against dehydration and stabilising the bioactive molecules. This biodegradable drug delivery vehicle at the nanoscale level exhibits a tendency to accumulate in the liver and muscles. The non-modification of drug adsorption onto the aquasome surface facilitates prompt pharmacological response by allowing unobstructed receptor recognition at the action site. Conclusions: Aquasome, a three-layered self-assembled molecule, is a simple yet new drug delivery system with promising carrier potentials to increase the solubility and bioavailability of poorly soluble drugs. Despite a host of challenges, such as time consumption, sophisticated processes, safety, and expensive research costs, aquasome may emerge as an alternative vesicular carrier in the future.

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“… Aquasomes Trilayered self-assembled nanostructures comprising a solid phase nanocrystalline. Bromelain Lack of in vivo data [ 101 ] Archaeosomes Vesicles composed of glycerolipids of archaea with potent adjuvant activity. Ovalbumin Enhancement in oral immunization [ 102 ] Colloidosomes Hollow shell microcapsules consisting of coagulated or fused particles at the interface of emulsion droplets Insulin Improvement in hypoglycemic effect [ 103 ] Cryptosomes Stealth liposomes or immune-liposomes with a surface coat of PEG or its derivatives.…”

Section: Introductionmentioning

confidence: 99%

Nanovesicles-Mediated Drug Delivery for Oral Bioavailability Enhancement

Ren¹,

Nie²,

Zhu³

et al. 2022

IJN

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Bioavailability is an eternal topic that cannot be circumvented by peroral drug delivery. Adequate blood drug exposure after oral administration is a prerequisite for effective treatment. Nanovesicles as pleiotropic oral vehicles can solubilize, encapsulate, stabilize an active ingredient and promote the payload absorption via various mechanisms. Vesicular systems with nanoscale size, such as liposomes, niosomes and polymersomes, provide a versatile platform for oral delivery of drugs with distinct nature. The amphiphilicity of vesicles in structure allows hydrophilic and lipophilic molecule(s) either or both to be loaded, being encapsulated in the aqueous cavity or the inner core, respectively. Depending on high oral transport efficiency based on their structural flexibility, gastrointestinal stability, biocompatibility, and/or intestinal epithelial affinity, nanovesicles can markedly augment the oral bioavailability of various poorly absorbed drugs. Vesicular drug delivery systems (VDDSs) demonstrate a lot of preferences and are becoming more prominent of late years in biomedical applications. Equally, these systems can potentiate a drug’s therapeutic index by ameliorating the oral absorption. This review devotes to comment on various VDDSs with special emphasis on the peroral drug delivery. The classification of nanovesicles, preparative processes, intestinal transport mechanisms, in vivo fate, and design rationale were expounded. Knowledge on vesicles-mediated oral drug delivery for bioavailability enhancement has been properly provided. It can be concluded that VDDSs with many merits will step into an energetic arena in oral drug delivery.

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Aquasomes as a Carrier System for Oral Delivery of Bromelain

Cited by 8 publications

References 10 publications

Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain

Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain

Aquasomal drug delivery system: A special emphasis on the formulation techniques and applications

Nanovesicles-Mediated Drug Delivery for Oral Bioavailability Enhancement

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