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Increasing the fill volume of a jet nebulizer is essential to increase the amount of inhaled medication reaching a subject. In contrast, there is no need to increase fill volumes when using a vibrating mesh nebulizer. There is no need to switch off the humidifier while delivering aerosol through a single-limb NIV circuit.

Introduction: Nebulizers used to deliver aerosol during non-invasive mechanical ventilation (NIV) have many types, each type has many different designs. This study aimed to determine the effect of nebulizer deign on aerosol delivery in NIV. Methods: Different designs of jet nebulizer (JN) and vibrating mesh nebulizer (VMN) were tested by placing 1 ml of salbutamol in a nebulizer chamber operated in an in vitro NIV setting using a breathing simulator with adult settings (inhalation-exhalation ratio 1:3, 15 breaths/

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